Protein Summary
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhib ...more
- ENST00000418390
- ENSP00000395574
- ENSG00000011007
- ENST00000613537
- ENSP00000484196
- TCEB3
- SIII
- TCEB3
- TCEB3A
- SIII p110
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.69 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 353 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.69 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 353 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (119)
LZTS2
Novelty: 0.09515452
p_int: 0.999881065
p_ni: 0.000118927
p_wrong: 8e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
ANTXR2
Novelty: 0.00632874
p_int: 0.964109201
p_ni: 0.005390922
p_wrong: 0.030499877
Score: 0.379
Data Source: BioPlex,STRINGDB
SLC13A2
Family: Transporter
Novelty: 0.01020451
p_int: 0.906736516
p_ni: 0.003073605
p_wrong: 0.090189879
Score: 0.345
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (144)
Reactome (22)
WikiPathways (122)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Formation of HIV elongation complex in the absence of HIV Tat | ||||
Reactome | Formation of HIV-1 elongation complex containing HIV-1 Tat | ||||
Reactome | Formation of RNA Pol II elongation complex | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Formation of HIV elongation complex in the absence of HIV Tat | ||||
Formation of HIV-1 elongation complex containing HIV-1 Tat | ||||
Formation of RNA Pol II elongation complex | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 4 | 6 | 92.4 | |||||
reticulocyte measurement | 3 | 2 | 3 | 90.5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 92.4 | |||||
reticulocyte measurement | 3 | 90.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | elongin A | VGNC:8530 | 456620 | |||||
Macaque | elongin A | 710467 | ||||||
Mouse | MGI:1351315 | 27224 | ||||||
Rat | RGD:3827 | 25562 | ||||||
Dog | elongin A | VGNC:54720 | 478188 | |||||
Publication Statistics
PubMed Score 25.69
PubMed score by year
PubTator Score 27.54
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (6)
Items per page:
0 of 0
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