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Tbio
ELOA
Elongin-A

Protein Summary
Description
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhib ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000418390
  • ENSP00000395574
  • ENSG00000011007
  • ENST00000613537
  • ENSP00000484196

Symbol
  • TCEB3
  • SIII
  • TCEB3
  • TCEB3A
  • SIII p110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.69   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 353   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.69   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999881065
p_ni:  0.000118927
p_wrong:  8e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
ANTXR2
Tchem
Novelty:  0.00632874
p_int:  0.964109201
p_ni:  0.005390922
p_wrong:  0.030499877
Score:  0.379
Data Source:  BioPlex,STRINGDB
SLC13A2
Tbio
Family:  Transporter
Novelty:  0.01020451
p_int:  0.906736516
p_ni:  0.003073605
p_wrong:  0.090189879
Score:  0.345
Data Source:  BioPlex,STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.996
Data Source:  Reactome,STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.988
Data Source:  Reactome,STRINGDB
LEO1
Tbio
Family:  Enzyme
Novelty:  0.00851903
Score:  0.974
Data Source:  STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.967
Data Source:  STRINGDB
CTR9
Tbio
Family:  Enzyme
Novelty:  0.04434964
Score:  0.957
Data Source:  STRINGDB
IWS1
Tbio
Novelty:  0.08732963
Score:  0.949
Data Source:  STRINGDB
GTF2F2
Tbio
Novelty:  0.02446629
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (144)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
6
92.4
reticulocyte measurement
3
2
3
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
92.4
reticulocyte measurement
3
90.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elongin A
VGNC:8530
456620
Macaque
elongin A
710467
Mouse
MGI:1351315
27224
Rat
RGD:3827
25562
Dog
elongin A
VGNC:54720
478188
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elongin A
Macaque
elongin A
Mouse
Rat
Dog
elongin A
Publication Statistics
PubMed Score 25.69
PubMed score by year
PubTator Score 27.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title