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Tbio
EIF4A2
Eukaryotic initiation factor 4A-II

Protein Summary
Description
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323963
  • ENSP00000326381
  • ENSG00000156976
  • ENST00000440191
  • ENSP00000398370

Symbol
  • DDX2B
  • EIF4F
  • DDX2B
  • EIF4A
  • EIF4F
  • BM-010
  • eIF4A-II
  • eIF-4A-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
molecular function
0.97
transcription factor binding site profile
0.94
interacting protein
0.93
cell type or tissue
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.3   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.3   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (312)
1 – 10 of 312
EIF4A1
Tchem
Novelty:  0.00269994
p_int:  0.999965491
p_ni:  0.000034509
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
EIF4E
Tchem
Novelty:  0.00072182
Score:  0.999
Data Source:  Reactome,STRINGDB
EIF4G1
Tbio
Novelty:  0.00170995
Score:  0.999
Data Source:  Reactome,STRINGDB
EIF4G3
Tbio
Novelty:  0.03002723
Score:  0.999
Data Source:  Reactome,STRINGDB
EIF4B
Tbio
Novelty:  0.00665561
Score:  0.998
Data Source:  Reactome,STRINGDB
PAIP1
Tbio
Novelty:  0.05922084
Score:  0.994
Data Source:  STRINGDB
PABPC1
Tbio
Novelty:  0.00197523
Score:  0.988
Data Source:  Reactome,STRINGDB
EIF1
Tbio
Novelty:  0.00590381
Score:  0.986
Data Source:  STRINGDB
EIF4G2
Tbio
Novelty:  0.01424739
Score:  0.985
Data Source:  Reactome,STRINGDB
EIF5B
Tchem
Novelty:  0.00119991
Score:  0.984
Data Source:  STRINGDB
Pathways (22)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cap-dependent Translation Initiation
Reactome
Cytokine Signaling in Immune system
Reactome
Deadenylation of mRNA
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Antiviral mechanism by IFN-stimulated genes
Cap-dependent Translation Initiation
Cytokine Signaling in Immune system
Deadenylation of mRNA
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
AgBase
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
6
6
7
99.1
BMI-adjusted adiponectin measurement
1
4
4
96.4
partial thromboplastin time
2
2
2
92.8
glomerular filtration rate
7
5
6
8.1
92
factor XI measurement
1
1
1
88.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
7
99.1
BMI-adjusted adiponectin measurement
4
96.4
partial thromboplastin time
2
92.8
glomerular filtration rate
6
8.1
92
factor XI measurement
1
88.4
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4A2
VGNC:11388
460917
Macaque
eukaryotic translation initiation factor 4A2
707775
Mouse
MGI:106906
13682
Rat
RGD:1309225
303831
Dog
eukaryotic translation initiation factor 4A2
VGNC:40280
488118
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4A2
Macaque
eukaryotic translation initiation factor 4A2
Mouse
Rat
Dog
eukaryotic translation initiation factor 4A2
Publication Statistics
PubMed Score 298.30
PubMed score by year
PubTator Score 91.41
PubTator score by year