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Tbio
EIF2B1
Translation initiation factor eIF-2B subunit alpha

Protein Summary
Description
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000424014
  • ENSP00000416250
  • ENSG00000111361
  • ENST00000537073
  • ENSP00000444183

Symbol
  • EIF2BA
  • EIF2B
  • EIF2BA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
0.97
histone modification site profile
0.91
kinase perturbation
0.88
biological process
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.18   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.18   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
11
11
94
BMI-adjusted waist-hip ratio
1
11
11
93.4
waist circumference
1
7
7
89.8
BMI-adjusted waist circumference
1
8
8
89.1
alkaline phosphatase measurement
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
11
94
BMI-adjusted waist-hip ratio
11
93.4
waist circumference
7
89.8
BMI-adjusted waist circumference
8
89.1
alkaline phosphatase measurement
1
67.1
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2B subunit alpha
VGNC:8404
467184
Macaque
eukaryotic translation initiation factor 2B subunit alpha
705438
Mouse
MGI:2384802
209354
Rat
RGD:620819
64514
Dog
eukaryotic translation initiation factor 2B subunit alpha
VGNC:40260
477447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2B subunit alpha
Macaque
eukaryotic translation initiation factor 2B subunit alpha
Mouse
Rat
Dog
eukaryotic translation initiation factor 2B subunit alpha
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14232-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cap-dependent Translation Initiation (R-HSA-72737)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Metabolism of proteins
Reactome
Recycling of eIF2:GDP
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Metabolism of proteins
Recycling of eIF2:GDP
Translation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (83)
1 – 10 of 83
EIF2B2
Tbio
Novelty:  0.03253919
p_int:  0.999999856
p_ni:  1.44e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.999916865
p_ni:  0.000083125
p_wrong:  1e-8
Data Source:  BioPlex
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.999909886
p_ni:  0.00009009
p_wrong:  2.4e-8
Score:  0.518
Data Source:  BioPlex,STRINGDB
BTC
Tbio
Novelty:  0.00673076
p_int:  0.999830928
p_ni:  0.000169072
Data Source:  BioPlex
CD226
Tbio
Novelty:  0.00374102
p_int:  0.997670949
p_ni:  0.00232905
p_wrong:  1e-9
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.994728044
p_ni:  0.005271947
p_wrong:  9e-9
Data Source:  BioPlex
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.994282211
p_ni:  0.005717788
Data Source:  BioPlex
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.990399156
p_ni:  0.009600844
Score:  0.999
Data Source:  BioPlex,STRINGDB
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.985821592
p_ni:  0.014178408
Data Source:  BioPlex
VTI1B
Tbio
Novelty:  0.00955467
p_int:  0.984141129
p_ni:  0.015858862
p_wrong:  8e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  38.18

PubMed score by year
PubTator Score  13.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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