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Tbio
DYNC1H1
Cytoplasmic dynein 1 heavy chain 1

Protein Summary
Description
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360184
  • ENSP00000348965
  • ENSG00000197102

Symbol
  • DHC1
  • DNCH1
  • DNCL
  • DNECL
  • DYHC
  • KIAA0325
  • p22
  • DHC1
  • DNCL
  • DYHC
  • HL-3
  • CMT2O
  • DHC1a
  • DNCH1
  • DNECL
  • Dnchc1
  • SMALED1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
hub protein
0.98
kinase perturbation
0.98
molecular function
0.98
transcription factor perturbation
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.87   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.87   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (569)
DYNC1I2
Tbio
Novelty:  0.00228615
p_int:  0.998307046
p_ni:  0.001692954
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
p_int:  0.994497295
p_ni:  0.005502705
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
DYNC1LI1
Tbio
Novelty:  0.02164556
p_int:  0.993061133
p_ni:  0.006938867
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RASEF
Tbio
Novelty:  0.08877022
p_int:  0.946725482
p_ni:  0.053274518
Score:  0.185
Data Source:  BioPlex,STRINGDB
TRAP1
Tchem
Novelty:  0.03344189
p_int:  0.915422609
p_ni:  0.084577391
Data Source:  BioPlex
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.801434663
p_ni:  0.198565337
Data Source:  BioPlex
DYNC1LI2
Tbio
Novelty:  0.17381295
Score:  0.999
Data Source:  Reactome,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
Score:  0.998
Data Source:  Reactome,STRINGDB
DCTN1
Tbio
Novelty:  0.00494896
Score:  0.998
Data Source:  Reactome,STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
Score:  0.998
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (54)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Anchoring of the basal body to the plasma membrane
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Anchoring of the basal body to the plasma membrane
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
FlyBase
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
50.6
creatinine measurement
1
1
1
33.1
blood protein measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
50.6
creatinine measurement
1
33.1
blood protein measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 1 heavy chain 1
VGNC:9048
453171
Macaque
dynein cytoplasmic 1 heavy chain 1
718989
Mouse
MGI:103147
13424
Rat
RGD:2511
29489
Dog
dynein cytoplasmic 1 heavy chain 1
VGNC:40143
480437
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 1 heavy chain 1
Macaque
dynein cytoplasmic 1 heavy chain 1
Mouse
Rat
Dog
dynein cytoplasmic 1 heavy chain 1
Publication Statistics
PubMed Score 112.87
PubMed score by year
PubTator Score 64.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title