Tbio DYNC1H1 Cytoplasmic dynein 1 heavy chain 1

Protein Summary

Description

Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q14204
• B0I1R0
• Q6DKQ7
• Q8WU28
• Q92814
• Q9Y4G5

Gene Name

• DYNC1H1

Ensembl ID

• ENST00000360184
• ENSP00000348965
• ENSG00000197102

Symbol

• DHC1
• DNCH1
• DNCL
• DNECL
• DYHC
• KIAA0325
• p22
• DHC1
• DNCL
• DYHC
• HL-3
• CMT2O
• DHC1a
• DNCH1
• DNECL
• Dnchc1
• SMALED1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
hub protein	0.98
kinase perturbation	0.98
molecular function	0.98
transcription factor perturbation	0.98

Protein Classes

PANTHER Classes

Protein / Hydrolase / Cytoplasmic Dynein 1 Heavy Chain 1

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Cytoplasmic Dynein 1 Heavy Chain 1

DTO Classes

Protein / Enzyme / Hydrolase / Cytoplasmic Dynein 1 Heavy Chain 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.98   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.98   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0