Tbio DYNC1H1 Cytoplasmic dynein 1 heavy chain 1

Protein Summary

Description

Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q14204
• B0I1R0
• Q6DKQ7
• Q8WU28
• Q92814
• Q9Y4G5

Gene Name

• DYNC1H1

Ensembl ID

• ENST00000360184
• ENSP00000348965
• ENSG00000197102

Symbol

• DHC1
• DNCH1
• DNCL
• DNECL
• DYHC
• KIAA0325
• p22
• DHC1
• DNCL
• DYHC
• HL-3
• CMT2O
• DHC1a
• DNCH1
• DNECL
• Dnchc1
• SMALED1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
hub protein	0.98
kinase perturbation	0.98
molecular function	0.98
transcription factor perturbation	0.98

Protein Classes

PANTHER Classes

Protein / Hydrolase / Cytoplasmic Dynein 1 Heavy Chain 1

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Cytoplasmic Dynein 1 Heavy Chain 1

DTO Classes

Protein / Enzyme / Hydrolase / Cytoplasmic Dynein 1 Heavy Chain 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.87   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.87   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (569)

Explore Interacting Targets

1 – 10 of 569

• See Interactions on String-DB

DYNC1I2

Tbio

Novelty:  0.00228615

p_int:  0.998307046

p_ni:  0.001692954

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

DYNC1I1

Tbio

Novelty:  0.12175372

p_int:  0.994497295

p_ni:  0.005502705

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

DYNC1LI1

Tbio

Novelty:  0.02164556

p_int:  0.993061133

p_ni:  0.006938867

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

RASEF

Tbio

Novelty:  0.08877022

p_int:  0.946725482

p_ni:  0.053274518

Score:  0.185

Data Source:  BioPlex,STRINGDB

TRAP1

Tchem

Novelty:  0.03344189

p_int:  0.915422609

p_ni:  0.084577391

Data Source:  BioPlex

CYP2J2

Tchem

Novelty:  0.00534181

p_int:  0.801434663

p_ni:  0.198565337

Data Source:  BioPlex

DYNC1LI2

Tbio

Novelty:  0.17381295

Score:  0.999

Data Source:  Reactome,STRINGDB

DCTN5

Tbio

Novelty:  0.19530162

Score:  0.998

Data Source:  Reactome,STRINGDB

DCTN1

Tbio

Novelty:  0.00494896

Score:  0.998

Data Source:  Reactome,STRINGDB

DCTN2

Tbio

Novelty:  0.01045432

Score:  0.998

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (54)

Reactome (47)

KEGG (3)

PathwayCommons (2)

WikiPathways (2)

AURKA Activation by TPX2 (R-HSA-8854518)

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1 – 5 of 47

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Reactome	Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Adaptive Immune System	894 targets	R-HSA-1280218
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (35)

Functions (6)

Components (10)

Processes (19)

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Items per page:

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1 – 6 of 6

GO Term	Evidence	Assigned by
dynein light intermediate chain binding	Inferred from Physical Interaction (IPI)	FlyBase
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ATP-dependent microtubule motor activity, minus-end-directed	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
dynein intermediate chain binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
dynein light chain binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	1	1	1		50.6
creatinine measurement	EFO_0004518	1	1	1		33.1
blood protein measurement	EFO_0007937	1	1	1		30.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	1		50.6
creatinine measurement	EFO_0004518	1		33.1
blood protein measurement	EFO_0007937	1		30.2

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UniProt Keyword Find Similar Targets

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3D-structure
Acetylation
ATP-binding
Cell cycle
Cell division
Charcot-Marie-Tooth disease
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
creatinine measurement
red blood cell distribution width

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
growth/size/body region phenotype
mortality/aging
muscle phenotype
nervous system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	dynein cytoplasmic 1 heavy chain 1	VGNC:9048	453171
Macaque	dynein cytoplasmic 1 heavy chain 1		718989
Mouse	dynein cytoplasmic 1 heavy chain 1	MGI:103147	13424
Rat	dynein cytoplasmic 1 heavy chain 1	RGD:2511	29489
Dog	dynein cytoplasmic 1 heavy chain 1	VGNC:40143	480437

Species	Name	OMA	EggNOG	Inparanoid
Chimp	dynein cytoplasmic 1 heavy chain 1
Macaque	dynein cytoplasmic 1 heavy chain 1
Mouse	dynein cytoplasmic 1 heavy chain 1
Rat	dynein cytoplasmic 1 heavy chain 1
Dog	dynein cytoplasmic 1 heavy chain 1

Publication Statistics

PubMed Score 112.87

PubMed score by year

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PubTator Score 64.76

PubTator score by year

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Related Publications

Text Mined References (89)

GeneRif Annotations (38)

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PMID	Year	Title