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Tbio
DCTN1
Dynactin subunit 1

Protein Summary
Description
Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361874
  • ENSP00000354791
  • ENSG00000204843
  • ENST00000394003
  • ENSP00000377571
  • ENST00000409240
  • ENSP00000386406
  • ENST00000409438
  • ENSP00000387270
  • ENST00000409567
  • ENSP00000386843
  • ENST00000633691
  • ENSP00000487724

Symbol
  • P135
  • DP-150
  • DAP-150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.91
transcription factor perturbation
0.84
biological process
0.82
transcription factor
0.81
hub protein
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.71   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.71   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (364)
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.999999999
p_ni:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999999994
p_ni:  6e-9
Score:  0.641
Data Source:  BioPlex,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.999999969
p_ni:  3.1e-8
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
DCTN2
Tbio
Novelty:  0.01045432
p_int:  0.999999934
p_ni:  6.6e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.999997074
p_ni:  0.000002925
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.999922827
p_ni:  0.000077162
p_wrong:  1.1e-8
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.999917194
p_ni:  0.000082806
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
DCTN4
Tbio
Novelty:  0.10319227
p_int:  0.999889872
p_ni:  0.000110128
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.99986763
p_ni:  0.00013237
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ACTR1A
Tbio
Novelty:  0.06306209
p_int:  0.99936814
p_ni:  0.00063186
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (40)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Adaptive Immune System
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Adaptive Immune System
Anchoring of the basal body to the plasma membrane
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (53)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
2
44.7
appendicular lean mass
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
44.7
appendicular lean mass
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynactin subunit 1
VGNC:216
459332
Macaque
dynactin subunit 1
708290
Mouse
MGI:107745
13191
Rat
RGD:62038
29167
Dog
dynactin subunit 1
VGNC:39816
483106
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynactin subunit 1
Macaque
dynactin subunit 1
Mouse
Rat
Dog
dynactin subunit 1
Publication Statistics
PubMed Score 220.71
PubMed score by year
PubTator Score 59.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title