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Tbio
MRPL58
Peptidyl-tRNA hydrolase ICT1, mitochondrial

Protein Summary
Description
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301585
  • ENSP00000301585
  • ENSG00000167862

Symbol
  • DS1
  • ICT1
  • DS1
  • DS-1
  • ICT1
  • MRP-L58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 594.9   (req: < 5)
View Publications
Gene RIFs: 12   (req: <= 3)
View Gene RIFs
Antibodies: 287   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 594.9   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L58
VGNC:11711
736364
Macaque
peptidyl-tRNA hydrolase ICT1, mitochondrial pseudogene
706710
Mouse
mitochondrial ribosomal protein L58
MGI:1915822
68572
Rat
mitochondrial ribosomal protein L58
RGD:1307942
303673
Dog
mitochondrial ribosomal protein L58
VGNC:43407
475911
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L58
Macaque
peptidyl-tRNA hydrolase ICT1, mitochondrial pseudogene
Mouse
mitochondrial ribosomal protein L58
Rat
mitochondrial ribosomal protein L58
Dog
mitochondrial ribosomal protein L58
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14197-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
2050 targets
R-HSA-392499
Reactome
Mitochondrial translation
96 targets
R-HSA-5368287
Reactome
Mitochondrial translation elongation
90 targets
R-HSA-5389840
Reactome
Mitochondrial translation initiation
90 targets
R-HSA-5368286
Reactome
Mitochondrial translation termination
90 targets
R-HSA-5419276
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
2050 targets
R-HSA-392499
Mitochondrial translation
96 targets
R-HSA-5368287
Mitochondrial translation elongation
90 targets
R-HSA-5389840
Mitochondrial translation initiation
90 targets
R-HSA-5368286
Mitochondrial translation termination
90 targets
R-HSA-5419276
Protein-Protein Interactions (272)
1 – 10 of 272
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.999917284
p_ni: 0.000082716
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.99975142
p_ni: 0.00024858
Score: 0.982
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.999224239
p_ni: 0.000775761
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.998941466
p_ni: 0.001058534
Score: 0.994
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.998701831
p_ni: 0.001298169
Score: 0.981
Data Source: BioPlex,STRINGDB
MRPL53
Tdark
Novelty: 1.0076471
p_int: 0.99870058
p_ni: 0.00129942
Score: 0.983
Data Source: BioPlex,STRINGDB
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.997475299
p_ni: 0.002524701
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.995698297
p_ni: 0.004301703
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.995129134
p_ni: 0.004870866
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.99210246
p_ni: 0.00789754
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  594.90

PubMed score by year
PubTator Score  106.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer