Tbio MRPL58 Peptidyl-tRNA hydrolase ICT1, mitochondrial

Protein Summary

Description

Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q14197
• B2RAD1
• Q53HM7
• Q53Y11

Gene Name

• MRPL58

Ensembl ID

• ENST00000301585
• ENSP00000301585
• ENSG00000167862

Symbol

• DS1
• ICT1
• DS1
• DS-1
• ICT1
• MRP-L58

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 606.47   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 606.47   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (272)

Explore Interacting Targets

1 – 10 of 272

• See Interactions on String-DB

MRPL18

Tbio

Novelty:  0.73438796

p_int:  0.999917284

p_ni:  0.000082716

Score:  0.998

Data Source:  BioPlex,STRINGDB

MRPL30

Tdark

Novelty:  1.03623556

p_int:  0.99975142

p_ni:  0.00024858

Score:  0.982

Data Source:  BioPlex,STRINGDB

MRPL50

Tdark

Novelty:  0.88879319

p_int:  0.999224239

p_ni:  0.000775761

Score:  0.995

Data Source:  BioPlex,STRINGDB

MRPS30

Tbio

Novelty:  0.08115544

p_int:  0.998941466

p_ni:  0.001058534

Score:  0.994

Data Source:  BioPlex,STRINGDB

MRPL10

Tbio

Novelty:  0.27087019

p_int:  0.998701831

p_ni:  0.001298169

Score:  0.981

Data Source:  BioPlex,STRINGDB

MRPL53

Tdark

Novelty:  1.0076471

p_int:  0.99870058

p_ni:  0.00129942

Score:  0.983

Data Source:  BioPlex,STRINGDB

MRPL13

Tbio

Novelty:  0.04173503

p_int:  0.997475299

p_ni:  0.002524701

Score:  0.998

Data Source:  BioPlex,STRINGDB

MRPL4

Tdark

Novelty:  0.27290276

p_int:  0.995698297

p_ni:  0.004301703

Score:  0.997

Data Source:  BioPlex,STRINGDB

MRPL47

Tbio

Novelty:  0.05648009

p_int:  0.995129134

p_ni:  0.004870866

Score:  0.998

Data Source:  BioPlex,STRINGDB

MRPL42

Tbio

Novelty:  0.48241447

p_int:  0.99210246

p_ni:  0.00789754

Score:  0.996

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (6)

Metabolism of proteins (R-HSA-392499)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial translation	96 targets	R-HSA-5368287
Reactome	Mitochondrial translation elongation	90 targets	R-HSA-5389840
Reactome	Mitochondrial translation initiation	90 targets	R-HSA-5368286
Reactome	Mitochondrial translation termination	90 targets	R-HSA-5419276

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial translation	96 targets	R-HSA-5368287
Mitochondrial translation elongation	90 targets	R-HSA-5389840
Mitochondrial translation initiation	90 targets	R-HSA-5368286
Mitochondrial translation termination	90 targets	R-HSA-5419276

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (2)

Components (4)

Processes (2)

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1 – 2 of 2

GO Term	Evidence	Assigned by
aminoacyl-tRNA hydrolase activity	Inferred from Direct Assay (IDA)	UniProtKB
translation release factor activity, codon nonspecific	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	1	1	1		66.3
ferritin measurement	EFO_0004459	1	1	1		55.2
lymphocyte percentage of leukocytes	EFO_0007993	2	2	2		55.2
intraocular pressure measurement	EFO_0004695	1	1	1		30.2
neutrophil percentage of leukocytes	EFO_0007990	2	1	2		10

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	1		66.3
ferritin measurement	EFO_0004459	1		55.2
lymphocyte percentage of leukocytes	EFO_0007993	2		55.2
intraocular pressure measurement	EFO_0004695	1		30.2
neutrophil percentage of leukocytes	EFO_0007990	2		10

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Hydrolase
Mitochondrion
Polymorphism
Protein biosynthesis
Reference proteome
Ribonucleoprotein
Ribosomal protein
Transit peptide

GWAS Trait Find Similar Targets

No Header	No Header
ferritin measurement
intraocular pressure measurement
lymphocyte count
lymphocyte percentage of leukocytes
neutrophil percentage of leukocytes

MGI Phenotype Find Similar Targets

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embryo phenotype
growth/size/body region phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein L58	VGNC:11711	736364
Macaque	peptidyl-tRNA hydrolase ICT1, mitochondrial pseudogene		706710
Mouse	mitochondrial ribosomal protein L58	MGI:1915822	68572
Rat	mitochondrial ribosomal protein L58	RGD:1307942	303673
Dog	mitochondrial ribosomal protein L58	VGNC:43407	475911

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein L58
Macaque	peptidyl-tRNA hydrolase ICT1, mitochondrial pseudogene
Mouse	mitochondrial ribosomal protein L58
Rat	mitochondrial ribosomal protein L58
Dog	mitochondrial ribosomal protein L58

Publication Statistics

PubMed Score 606.47

PubMed score by year

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PubTator Score 106.49

PubTator score by year

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Related Publications

Text Mined References (25)

GeneRif Annotations (12)

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10

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PMID	Year	Title