CRMP1
Dihydropyrimidinase-related protein 1
Protein Summary
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
- ENST00000324989
- ENSP00000321606
- ENSG00000072832
- ENST00000397890
- ENSP00000380987
- DPYSL1
- ULIP3
- DRP1
- DRP-1
- CRMP-1
- DPYSL1
- ULIP-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.96 | ||
PubMedID | 0.8 | ||
kinase | 0.77 | ||
hub protein | 0.67 | ||
transcription factor | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.1 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 387 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.1 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 387 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0