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Tbio
FHL2
Four and a half LIM domains protein 2

Protein Summary
Description
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322142
  • ENSP00000322909
  • ENSG00000115641
  • ENST00000358129
  • ENSP00000350846
  • ENST00000393352
  • ENSP00000377020
  • ENST00000393353
  • ENSP00000377021
  • ENST00000408995
  • ENSP00000386633
  • ENST00000409807
  • ENSP00000386665

Symbol
  • DRAL
  • SLIM3
  • DRAL
  • AAG11
  • FHL-2
  • SLIM3
  • SLIM-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
PubMedID
0.96
transcription factor perturbation
0.96
virus perturbation
0.95
cellular component
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.36   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.36   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
household income
1
1
1
16
myeloid white cell count
1
1
1
5.2
pulse pressure measurement
1
1
1
2.8
platelet count
1
1
1
1.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
household income
1
16
myeloid white cell count
1
5.2
pulse pressure measurement
1
2.8
platelet count
1
1.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
four and a half LIM domains 2
VGNC:10648
459469
Macaque
four and a half LIM domains 2
713222
Mouse
MGI:1338762
14200
Rat
RGD:61963
63839
Dog
four and a half LIM domains 2
VGNC:40872
474544
Species
Name
OMA
EggNOG
Inparanoid
Chimp
four and a half LIM domains 2
Macaque
four and a half LIM domains 2
Mouse
Rat
Dog
four and a half LIM domains 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14192-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (199)
1 – 10 of 199
NACC2
Tbio
Novelty: 0.03937051
p_int: 0.999345458
p_ni: 0.000654542
Data Source: BioPlex
RIBC1
Tdark
Novelty: 0.40435429
p_int: 0.996100244
p_ni: 0.003899543
p_wrong: 2.12e-7
Data Source: BioPlex
NANOS2
Tbio
Novelty: 0.01489157
p_int: 0.995183895
p_ni: 0.004816092
p_wrong: 1.3e-8
Data Source: BioPlex
CNOT11
Tbio
Novelty: 0.01687183
p_int: 0.994939609
p_ni: 0.005060249
p_wrong: 1.42e-7
Score: 0.386
Data Source: BioPlex,STRINGDB
CAVIN1
Tbio
Family: Enzyme
Novelty: 0.00780634
p_int: 0.994881388
p_ni: 0.004942657
p_wrong: 0.000175955
Score: 0.958
Data Source: BioPlex,STRINGDB
CNOT3
Tbio
Novelty: 0.02463568
p_int: 0.99331181
p_ni: 0.006688158
p_wrong: 3.2e-8
Data Source: BioPlex
USF1
Tbio
Family: TF
Novelty: 0.00136587
p_int: 0.991330088
p_ni: 0.008669912
Score: 0.175
Data Source: BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty: 0.003692
p_int: 0.989511049
p_ni: 0.010488934
p_wrong: 1.7e-8
Data Source: BioPlex
DSN1
Tbio
Novelty: 0.05336903
p_int: 0.989131324
p_ni: 0.010752547
p_wrong: 0.000116129
Data Source: BioPlex
EPB41L5
Tbio
Novelty: 0.0391959
p_int: 0.988289181
p_ni: 0.011703021
p_wrong: 0.000007799
Data Source: BioPlex
Publication Statistics
PubMed Score  224.36

PubMed score by year
PubTator Score  123.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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