FHL2
Four and a half LIM domains protein 2
Protein Summary
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced ...more
- ENST00000322142
- ENSP00000322909
- ENSG00000115641
- ENST00000358129
- ENSP00000350846
- ENST00000393352
- ENSP00000377020
- ENST00000393353
- ENSP00000377021
- ENST00000408995
- ENSP00000386633
- ENST00000409807
- ENSP00000386665
- DRAL
- SLIM3
- DRAL
- AAG11
- FHL-2
- SLIM3
- SLIM-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.96 | ||
PubMedID | 0.96 | ||
transcription factor perturbation | 0.96 | ||
virus perturbation | 0.95 | ||
cellular component | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 284.56 (req: < 5)
Gene RIFs: 98 (req: <= 3)
Antibodies: 320 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 284.56 (req: >= 5)
Gene RIFs: 98 (req: > 3)
Antibodies: 320 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0