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Tbio
WRN
Werner syndrome ATP-dependent helicase

Protein Summary
Description
Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation. This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298139
  • ENSP00000298139
  • ENSG00000165392

Symbol
  • RECQ3
  • RECQL2
  • RECQ3
  • RECQL2
  • RECQL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
biological process
0.78
cellular component
0.74
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.43   (req: < 5)
Gene RIFs: 218   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.43   (req: >= 5)
Gene RIFs: 218   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
1
3
88.3
self reported educational attainment
2
2
2
79.8
intelligence
2
1
1
5.9
69.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
88.3
self reported educational attainment
2
79.8
intelligence
1
5.9
69.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Werner syndrome RecQ like helicase
VGNC:7604
472732
Macaque
Werner syndrome RecQ like helicase
695678
Mouse
MGI:109635
22427
Rat
RGD:1564788
290805
Dog
Werner syndrome RecQ like helicase
493997
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Werner syndrome RecQ like helicase
Macaque
Werner syndrome RecQ like helicase
Mouse
Rat
Dog
Werner syndrome RecQ like helicase
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14191-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
G2/M Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
G2/M Checkpoints
Gene Ontology Terms (67)
Items per page:
10
1 – 10 of 26
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (311)
1 – 10 of 311
XRCC6
Tbio
Novelty: 0.00127955
p_int: 0.999999985
p_ni: 1.2e-8
p_wrong: 3e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
PDP1
Tbio
Family: Enzyme
Novelty: 0.00442352
p_int: 0.999955552
p_ni: 0.000044418
p_wrong: 3e-8
Data Source: BioPlex
SKAP1
Tbio
Family: Enzyme
Novelty: 0.03753848
p_int: 0.982684747
p_ni: 0.017315165
p_wrong: 8.8e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
KIAA0930
Tbio
Novelty: 0.16492958
p_int: 0.946382606
p_ni: 0.0514778
p_wrong: 0.002139594
Score: 0.219
Data Source: BioPlex,STRINGDB
RPA1
Tchem
Novelty: 0.00212665
Score: 0.999
Data Source: Reactome,STRINGDB
RPA2
Tbio
Novelty: 0.00879115
Score: 0.999
Data Source: Reactome,STRINGDB
RPA3
Tbio
Novelty: 0.00887858
Score: 0.999
Data Source: Reactome,STRINGDB
EXO1
Tbio
Family: Enzyme
Novelty: 0.00130104
Score: 0.996
Data Source: STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.995
Data Source: Reactome,STRINGDB
RAD52
Tbio
Novelty: 0.00125282
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  709.43

PubMed score by year
PubTator Score  463.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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