You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SIM2
Single-minded homolog 2

Protein Summary
Description
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290399
  • ENSP00000290399
  • ENSG00000159263

Symbol
  • BHLHE15
  • SIM
  • bHLHe15
  • HMC13F06
  • HMC29C01
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
protein domain
0.85
microRNA
0.76
tissue sample
0.7
biological process
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.53   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.53   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
5
5
92
hemoglobin measurement
2
4
4
89.8
erythrocyte count
1
1
1
49.5
hip circumference
1
2
2
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
5
92
hemoglobin measurement
4
89.8
erythrocyte count
1
49.5
hip circumference
2
38.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SIM bHLH transcription factor 2
VGNC:10507
474107
Mouse
MGI:98307
20465
Rat
RGD:1308016
304071
Dog
SIM bHLH transcription factor 2
VGNC:46175
607987
Opossum
single-minded family bHLH transcription factor 2
100022495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SIM bHLH transcription factor 2
Mouse
Rat
Dog
SIM bHLH transcription factor 2
Opossum
single-minded family bHLH transcription factor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14190-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (43)
1 – 10 of 43
ARNT2
Tbio
Family:  TF
Novelty:  0.01485424
p_int:  0.999862726
p_ni:  8e-9
p_wrong:  0.000137266
Score:  0.878
Data Source:  BioPlex,STRINGDB
FOXR2
Tbio
Family:  TF
Novelty:  0.06548862
p_int:  0.987633715
p_ni:  4.8e-8
p_wrong:  0.012366236
Score:  0.268
Data Source:  BioPlex,STRINGDB
ARNT
Tbio
Family:  TF
Novelty:  0.00183071
Score:  0.846
Data Source:  STRINGDB
OTP
Tbio
Family:  TF
Novelty:  0.01535446
Score:  0.784
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.755
Data Source:  STRINGDB
DCXR
Tbio
Family:  Enzyme
Novelty:  0.00967328
Score:  0.716
Data Source:  STRINGDB
PCP4
Tbio
Novelty:  0.00940968
Score:  0.701
Data Source:  STRINGDB
RNF165
Tdark
Novelty:  0.83518935
Score:  0.63
Data Source:  STRINGDB
PIAS1
Tbio
Family:  TF
Novelty:  0.00987743
Score:  0.583
Data Source:  STRINGDB
POU3F2
Tbio
Family:  TF
Novelty:  0.00649458
Score:  0.569
Data Source:  STRINGDB
Publication Statistics
PubMed Score  135.53

PubMed score by year
PubTator Score  68.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: