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Tbio
SIM2
Single-minded homolog 2

Protein Summary
Description
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290399
  • ENSP00000290399
  • ENSG00000159263

Symbol
  • BHLHE15
  • SIM
  • bHLHe15
  • HMC13F06
  • HMC29C01
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
protein domain
0.85
microRNA
0.76
tissue sample
0.7
biological process
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.77   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.77   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (43)
1 – 10 of 43
ARNT2
Tbio
Family: TF
Novelty: 0.02085597
p_int: 0.999862726
p_ni: 8e-9
p_wrong: 0.000137266
Score: 0.878
Data Source: BioPlex,STRINGDB
FOXR2
Tbio
Family: TF
Novelty: 0.10966838
p_int: 0.987633715
p_ni: 4.8e-8
p_wrong: 0.012366236
Score: 0.268
Data Source: BioPlex,STRINGDB
ARNT
Tbio
Family: TF
Novelty: 0.00291828
Score: 0.846
Data Source: STRINGDB
OTP
Tbio
Family: TF
Novelty: 0.00597958
Score: 0.784
Data Source: STRINGDB
SUMO1
Tbio
Novelty: 0.00169202
Score: 0.755
Data Source: STRINGDB
DCXR
Tbio
Family: Enzyme
Novelty: 0.00064186
Score: 0.716
Data Source: STRINGDB
PCP4
Tbio
Novelty: 0.0119396
Score: 0.701
Data Source: STRINGDB
RNF165
Tdark
Novelty: 2.14285714
Score: 0.63
Data Source: STRINGDB
PIAS1
Tbio
Family: TF
Novelty: 0.01153358
Score: 0.583
Data Source: STRINGDB
POU3F2
Tbio
Family: TF
Novelty: 0.00704703
Score: 0.569
Data Source: STRINGDB
Publication Statistics
PubMed Score  88.77

PubMed score by year
PubTator Score  68.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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