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Tbio
TFDP2
Transcription factor Dp-2

Protein Summary
Description
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000467072
  • ENSP00000418590
  • ENSG00000114126
  • ENST00000477292
  • ENSP00000418971
  • ENST00000479040
  • ENSP00000417585
  • ENST00000486111
  • ENSP00000420599
  • ENST00000489671
  • ENSP00000420616
  • ENST00000495310
  • ENSP00000419036
  • ENST00000499676
  • ENSP00000439782

Symbol
  • DP2
  • DP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
virus perturbation
1
transcription factor perturbation
0.97
kinase perturbation
0.81
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.31   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.31   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
7
7
9.3
94
cortical surface area measurement
1
1
0
956.8
93.5
vitamin D measurement
2
2
2
88.8
creatinine measurement
3
3
3
79.5
mean reticulocyte volume
1
1
1
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
9.3
94
cortical surface area measurement
0
956.8
93.5
vitamin D measurement
2
88.8
creatinine measurement
3
79.5
mean reticulocyte volume
1
47.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor Dp-2
VGNC:9700
460743
Macaque
transcription factor Dp-2
714655
Mouse
MGI:107167
211586
Rat
RGD:1305814
300947
Dog
transcription factor Dp-2
VGNC:47292
477099
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor Dp-2
Macaque
transcription factor Dp-2
Mouse
Rat
Dog
transcription factor Dp-2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (520)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of NOXA and translocation to mitochondria
Reactome
Activation of PUMA and translocation to mitochondria
Reactome
Apoptosis
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
Apoptosis
Cell Cycle
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
ProtInc
Protein-Protein Interactions (65)
1 – 10 of 65
E2F2
Tbio
Family: TF
Novelty: 0.00418995
p_int: 0.999999997
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
E2F6
Tbio
Family: TF
Novelty: 0.00753541
p_int: 0.999999994
p_ni: 6e-9
Score: 0.889
Data Source: BioPlex,Reactome,STRINGDB
E2F4
Tbio
Family: TF
Novelty: 0.00317412
p_int: 0.999999963
p_ni: 3.3e-8
p_wrong: 5e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
E2F3
Tbio
Family: TF
Novelty: 0.00287552
p_int: 0.999999961
p_ni: 3.9e-8
Score: 0.952
Data Source: BioPlex,Reactome,STRINGDB
PCGF6
Tbio
Novelty: 0.07032909
p_int: 0.999999389
p_ni: 6.05e-7
p_wrong: 7e-9
Score: 0.245
Data Source: BioPlex,STRINGDB
E2F5
Tbio
Family: TF
Novelty: 0.00674159
p_int: 0.99999919
p_ni: 3.53e-7
p_wrong: 4.56e-7
Score: 0.977
Data Source: BioPlex,Reactome,STRINGDB
E2F1
Tbio
Family: TF
Novelty: 0.00277137
p_int: 0.999998964
p_wrong: 0.000001036
Score: 0.925
Data Source: BioPlex,Reactome,STRINGDB
L3MBTL2
Tbio
Family: Epigenetic
Novelty: 0.11193867
p_int: 0.999998891
p_ni: 4.28e-7
p_wrong: 6.81e-7
Data Source: BioPlex
COMMD8
Tdark
Novelty: 0.33240242
p_int: 0.99998618
p_ni: 0.000013803
p_wrong: 1.7e-8
Data Source: BioPlex
RB1
Tchem
Novelty: 0.00063798
p_int: 0.998473366
p_ni: 0.001526634
Score: 0.975
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  6.31

PubMed score by year
PubTator Score  99.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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