Tbio TFDP1 Transcription factor Dp-1

Protein Summary

Description

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q14186
• B4DLQ9
• Q5JSB4
• Q8IZL5

Gene Name

• TFDP1

Ensembl ID

• ENST00000375370
• ENSP00000364519
• ENSG00000198176

Symbol

• DP1
• DP1
• DILC
• Dp-1
• DRTF1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
biological process	0.9
co-expressed gene	0.89
drug perturbation	0.87
virus perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Dp-1

Protein / Nucleic Acid Binding / Transcription Factor Dp-1

DTO Classes

Protein / Nucleic Acid Binding / Transcription Factor Dp-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.02   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 345   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.02   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0