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Tbio
TFDP1
Transcription factor Dp-1

Protein Summary
Description
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375370
  • ENSP00000364519
  • ENSG00000198176

Symbol
  • DP1
  • DP1
  • DILC
  • Dp-1
  • DRTF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
biological process
0.9
co-expressed gene
0.89
drug perturbation
0.87
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.77   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 345   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.77   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
14.7
body height
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
14.7
body height
1
2.9
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (73)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of NOXA and translocation to mitochondria
Reactome
Activation of PUMA and translocation to mitochondria
Reactome
Apoptosis
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
Apoptosis
Cell Cycle
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (166)
1 – 10 of 166
PCGF6
Tbio
Novelty: 0.07032909
p_int: 0.999999462
p_ni: 5.32e-7
p_wrong: 6e-9
Score: 0.979
Data Source: BioPlex,Reactome,STRINGDB
L3MBTL2
Tbio
Family: Epigenetic
Novelty: 0.11193867
p_int: 0.99999908
p_ni: 9.01e-7
p_wrong: 2e-8
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
GGA1
Tbio
Novelty: 0.00866392
p_int: 0.999995225
p_ni: 0.000004666
p_wrong: 1.09e-7
Data Source: BioPlex
MAX
Tbio
Family: TF
Novelty: 0.00799068
p_int: 0.999986133
p_ni: 0.00000937
p_wrong: 0.000004497
Score: 0.931
Data Source: BioPlex,Reactome,STRINGDB
COMMD8
Tdark
Novelty: 0.33240242
p_int: 0.999979506
p_ni: 0.00001943
p_wrong: 0.000001064
Score: 0.65
Data Source: BioPlex,STRINGDB
COMMD1
Tbio
Novelty: 0.01349432
p_int: 0.999970913
p_ni: 0.000029087
Score: 0.829
Data Source: BioPlex,STRINGDB
RYBP
Tbio
Novelty: 0.01140945
p_int: 0.999923694
p_ni: 0.000076299
p_wrong: 7e-9
Score: 0.975
Data Source: BioPlex,STRINGDB
E2F6
Tbio
Family: TF
Novelty: 0.00753541
p_int: 0.999850469
p_ni: 0.000149472
p_wrong: 5.9e-8
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
MIER2
Tbio
Novelty: 0.85226416
p_int: 0.999837416
p_ni: 0.000148654
p_wrong: 0.00001393
Score: 0.737
Data Source: BioPlex,STRINGDB
GMNN
Tbio
Novelty: 0.00436572
p_int: 0.999808914
p_ni: 0.000179545
p_wrong: 0.000011541
Score: 0.187
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  50.77

PubMed score by year
PubTator Score  123.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer