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Tbio
POLA2
DNA polymerase alpha subunit B

Protein Summary
Description
May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265465
  • ENSP00000265465
  • ENSG00000014138
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.91
transcription factor perturbation
0.91
pathway
0.71
transcription factor binding site profile
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.24   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.24   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase alpha 2, accessory subunit
VGNC:8302
451318
Macaque
DNA polymerase alpha 2, accessory subunit
716541
Mouse
MGI:99690
18969
Rat
RGD:621817
85242
Dog
DNA polymerase alpha 2, accessory subunit
VGNC:44772
476025
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase alpha 2, accessory subunit
Macaque
DNA polymerase alpha 2, accessory subunit
Mouse
Rat
Dog
DNA polymerase alpha 2, accessory subunit
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
Activation of the pre-replicative complex (R-HSA-68962)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Replication
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Replication
Protein-Protein Interactions (205)
1 – 10 of 205
PRIM1
Tbio
Family: Enzyme
Novelty: 0.0530384
p_int: 0.99999974
p_ni: 2.6e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
p_int: 0.999952355
p_ni: 0.000047645
Score: 0.189
Data Source: BioPlex,STRINGDB
BTF3
Tbio
Novelty: 0.01198537
p_int: 0.995877175
p_ni: 0.004122825
Data Source: BioPlex
TKT
Tchem
Family: Enzyme
Novelty: 0.00333936
p_int: 0.986298406
p_ni: 0.01370159
p_wrong: 4e-9
Data Source: BioPlex
LGALS7
Tbio
Novelty: 0.00753996
p_int: 0.974403799
p_ni: 0.025596195
p_wrong: 6e-9
Data Source: BioPlex
SNX21
Tdark
Novelty: 0.32916633
p_int: 0.944052684
p_ni: 0.055947275
p_wrong: 4e-8
Data Source: BioPlex
ZBBX
Tdark
Novelty: 1.66474399
p_int: 0.930131911
p_ni: 0.069867998
p_wrong: 9.1e-8
Data Source: BioPlex
LRRC27
Tdark
Novelty: 2.37640076
p_int: 0.857053108
p_ni: 0.142946657
p_wrong: 2.35e-7
Score: 0.18
Data Source: BioPlex,STRINGDB
ARPC5
Tbio
Novelty: 0.03434234
p_int: 0.851332765
p_ni: 0.148667069
p_wrong: 1.66e-7
Data Source: BioPlex
SSH3
Tbio
Family: Enzyme
Novelty: 0.11388661
p_int: 0.81089969
p_ni: 0.18908622
p_wrong: 0.00001409
Score: 0.192
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.24

PubMed score by year
PubTator Score  3.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer