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Tbio
TTLL12
Tubulin--tyrosine ligase-like protein 12

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216129
  • ENSP00000216129
  • ENSG00000100304

Symbol
  • KIAA0153
  • dJ526I14.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
kinase perturbation
0.81
histone modification site profile
0.8
transcription factor binding site profile
0.71
transcription factor
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.88   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.88   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
32.6
platelet count
1
1
1
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
32.6
platelet count
1
26.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase like 12
VGNC:5992
458888
Macaque
tubulin tyrosine ligase like 12
714871
Mouse
MGI:3039573
223723
Rat
RGD:1305319
300105
Dog
tubulin tyrosine ligase like 12
VGNC:47975
474474
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase like 12
Macaque
tubulin tyrosine ligase like 12
Mouse
Rat
Dog
tubulin tyrosine ligase like 12
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
EEF1A1
Tchem
Novelty: 0.00059953
p_int: 0.999993662
p_ni: 0.000006338
Score: 0.915
Data Source: BioPlex,STRINGDB
PBDC1
Tdark
Novelty: 0.79983498
p_int: 0.999990971
p_ni: 0.000009029
Score: 0.917
Data Source: BioPlex,STRINGDB
EEF1AKMT1
Tdark
Family: Enzyme
Novelty: 0.22249584
p_int: 0.999932644
p_ni: 0.000067356
Score: 0.843
Data Source: BioPlex,STRINGDB
DNAJB1
Tbio
Novelty: 0.00139956
p_int: 0.999887419
p_ni: 0.000112581
Score: 0.817
Data Source: BioPlex,STRINGDB
EEF1A2
Tchem
Novelty: 0.001472
p_int: 0.996579789
p_ni: 0.003420211
Score: 0.803
Data Source: BioPlex,STRINGDB
DNAJB4
Tbio
Novelty: 0.03467352
p_int: 0.992796758
p_ni: 0.007203242
Score: 0.602
Data Source: BioPlex,STRINGDB
DHX57
Tdark
Family: Enzyme
Novelty: 0.8244078
p_int: 0.982924022
p_ni: 0.017075978
Score: 0.333
Data Source: BioPlex,STRINGDB
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.872598241
p_ni: 0.127401759
Data Source: BioPlex
UBE2C
Tbio
Novelty: 0.00731185
Score: 0.828
Data Source: STRINGDB
SRXN1
Tbio
Novelty: 0.00780861
Score: 0.826
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.88

PubMed score by year
PubTator Score  5.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer