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Tbio
MLEC
Malectin

Protein Summary
Description
Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity). This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228506
  • ENSP00000228506
  • ENSG00000110917

Symbol
  • KIAA0152
  • KIAA0152
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.99
transcription factor binding site profile
0.88
disease perturbation
0.79
cell type or tissue
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.34   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.34   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
4
5
5
99.1
serum metabolite measurement
3
4
5
98.2
C-reactive protein measurement
2
12
13
98.1
serum gamma-glutamyl transferase measurement
1
11
11
97.2
red blood cell distribution width
4
3
4
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
5
99.1
serum metabolite measurement
5
98.2
C-reactive protein measurement
13
98.1
serum gamma-glutamyl transferase measurement
11
97.2
red blood cell distribution width
4
95.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
malectin
697934
Mouse
MGI:1924015
109154
Rat
Dog
malectin
VGNC:43256
609274
Horse
malectin
VGNC:20208
100050056
Species
Name
OMA
EggNOG
Inparanoid
Macaque
malectin
Mouse
Rat
Dog
malectin
Horse
malectin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14165-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Immune System
Innate Immune System
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (115)
1 – 10 of 115
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
p_int:  0.952688881
p_ni:  0.047311119
Score:  0.589
Data Source:  BioPlex,STRINGDB
PGRMC1
Tchem
Novelty:  0.00364386
Score:  0.934
Data Source:  STRINGDB
PTPRJ
Tbio
Family:  Enzyme
Novelty:  0.00786921
Score:  0.917
Data Source:  STRINGDB
GANAB
Tchem
Family:  Enzyme
Novelty:  0.01211958
Score:  0.914
Data Source:  Reactome,STRINGDB
PRKCSH
Tbio
Family:  Enzyme
Novelty:  0.00787916
Score:  0.91
Data Source:  Reactome,STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.907
Data Source:  STRINGDB
CYBB
Tchem
Family:  IC
Novelty:  0.00054866
Score:  0.904
Data Source:  STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.904
Data Source:  STRINGDB
PLAU
Tchem
Family:  Enzyme
Novelty:  0.0005322
Score:  0.904
Data Source:  STRINGDB
AGPAT2
Tchem
Family:  Enzyme
Novelty:  0.01321334
Score:  0.904
Data Source:  STRINGDB
Publication Statistics
PubMed Score  79.34

PubMed score by year
PubTator Score  14.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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