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Tchem
IKBKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Protein Summary
Description
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000581977
  • ENSP00000464030
  • ENSG00000263528
  • ENST00000584998
  • ENSP00000462396

Symbol
  • IKKE
  • IKKI
  • KIAA0151
  • IKKE
  • IKKI
  • IKK-E
  • IKK-i
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
hub protein
1
co-expressed gene
0.97
molecular function
0.97
interacting protein
0.91


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.05   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 533   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.05   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 533   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 52
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
79.3
monocyte count
1
1
1
44.4
eosinophil percentage of leukocytes
1
1
1
26.3
lymphocyte percentage of leukocytes
1
1
1
20
eosinophil count
1
1
1
20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
79.3
monocyte count
1
44.4
eosinophil percentage of leukocytes
1
26.3
lymphocyte percentage of leukocytes
1
20
eosinophil count
1
20
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inhibitor of nuclear factor kappa B kinase subunit epsilon
VGNC:14801
742813
Mouse
MGI:1929612
56489
Rat
RGD:1308352
363984
Dog
inhibitor of nuclear factor kappa B kinase subunit epsilon
VGNC:41921
478950
Horse
inhibitor of nuclear factor kappa B kinase subunit epsilon
VGNC:18985
100055384
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inhibitor of nuclear factor kappa B kinase subunit epsilon
Mouse
Rat
Dog
inhibitor of nuclear factor kappa B kinase subunit epsilon
Horse
inhibitor of nuclear factor kappa B kinase subunit epsilon
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14164-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (49)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Metabolism of proteins
Gene Ontology Terms (28)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (103)
1 – 10 of 103
MAVS
Tbio
Novelty: 0.00241215
Score: 0.995
Data Source: Reactome,STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.995
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.994
Data Source: Reactome,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.988
Data Source: Reactome,STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.987
Data Source: Reactome,STRINGDB
TANK
Tbio
Novelty: 0.01003866
Score: 0.986
Data Source: Reactome,STRINGDB
SIKE1
Tbio
Novelty: 0.14549184
Score: 0.983
Data Source: Reactome,STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
Score: 0.982
Data Source: Reactome,STRINGDB
IFIH1
Tbio
Family: Enzyme
Novelty: 0.00111499
Score: 0.979
Data Source: Reactome,STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.978
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  64.05

PubMed score by year
PubTator Score  75.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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