SCARF1
Scavenger receptor class F member 1
Protein Summary
Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
- ENST00000263071
- ENSP00000263071
- ENSG00000074660
- ENST00000434376
- ENSP00000411167
- ENST00000571272
- ENSP00000458174
- ENST00000621348
- ENSP00000481595
- ENSG00000276336
- ENST00000631462
- ENSP00000487665
- ENST00000632317
- ENSP00000488776
- KIAA0149
- SREC
- SREC
- SREC1
- SREC-I
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.77 | ||
cell type or tissue | 0.73 | ||
tissue sample | 0.71 | ||
biological process | 0.65 | ||
kinase perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 107.14 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 137 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 107.14 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 137 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (43)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Scavenging by Class F Receptors | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Scavenging by Class F Receptors | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (34)
Items per page:
1 – 5 of 34
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
serum albumin measurement | 3 | 5 | 6 | 96.9 | ||||||
serum albumin measurement | 3 | 5 | 6 | 96.9 | ||||||
sex hormone-binding globulin measurement | 6 | 3 | 8 | 96.6 | ||||||
sex hormone-binding globulin measurement | 6 | 3 | 8 | 96.6 | ||||||
alkaline phosphatase measurement | 2 | 2 | 2 | 12 | 92.3 | |||||
Items per page:
1 – 5 of 34
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum albumin measurement | 6 | 96.9 | |||||
serum albumin measurement | 6 | 96.9 | |||||
sex hormone-binding globulin measurement | 8 | 96.6 | |||||
sex hormone-binding globulin measurement | 8 | 96.6 | |||||
alkaline phosphatase measurement | 2 | 12 | 92.3 | ||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | scavenger receptor class F member 1 | VGNC:51731 | 747264 | |||||
Macaque | scavenger receptor class F member 1 | 721235 | ||||||
Mouse | MGI:2449455 | 380713 | ||||||
Cow | scavenger receptor class F member 1 | VGNC:34326 | 616566 | |||||
Pig | scavenger receptor class F member 1 | 100623100 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | scavenger receptor class F member 1 | |||||
Macaque | scavenger receptor class F member 1 | |||||
Mouse | ||||||
Cow | scavenger receptor class F member 1 | |||||
Pig | scavenger receptor class F member 1 | |||||
Publication Statistics
PubMed Score 107.14
PubMed score by year
PubTator Score 28.20
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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