SCARF1
Scavenger receptor class F member 1
Protein Classes
Protein Summary
Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
- ENST00000263071
- ENSP00000263071
- ENSG00000074660
- ENST00000434376
- ENSP00000411167
- ENST00000571272
- ENSP00000458174
- ENST00000621348
- ENSP00000481595
- ENSG00000276336
- ENST00000631462
- ENSP00000487665
- ENST00000632317
- ENSP00000488776
- KIAA0149
- SREC
- SREC
- SREC1
- SREC-I
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.77 | ||
cell type or tissue | 0.73 | ||
tissue sample | 0.71 | ||
biological process | 0.65 | ||
kinase perturbation | 0.6 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 107.19 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 137 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 107.19 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 137 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 1 | 1 | 1 | 45.3 | ||||||
reticulocyte measurement | 1 | 1 | 1 | 45.3 | ||||||
reticulocyte count | 1 | 1 | 1 | 44.9 | ||||||
reticulocyte count | 1 | 1 | 1 | 44.9 | ||||||
1 | 1 | 0 | 2.6 | 36.9 | ||||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 1 | 45.3 | |||||
reticulocyte measurement | 1 | 45.3 | |||||
reticulocyte count | 1 | 44.9 | |||||
reticulocyte count | 1 | 44.9 | |||||
0 | 2.6 | 36.9 | |||||
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | scavenger receptor class F member 1 | VGNC:51731 | 747264 | |||||
Macaque | scavenger receptor class F member 1 | 721235 | ||||||
Mouse | MGI:2449455 | 380713 | ||||||
Cow | scavenger receptor class F member 1 | VGNC:34326 | 616566 | |||||
Pig | scavenger receptor class F member 1 | 100623100 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | scavenger receptor class F member 1 | |||||
Macaque | scavenger receptor class F member 1 | |||||
Mouse | ||||||
Cow | scavenger receptor class F member 1 | |||||
Pig | scavenger receptor class F member 1 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Scavenging by Class F Receptors | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Scavenging by Class F Receptors | ||||
Vesicle-mediated transport | ||||
Gene Ontology Terms (13)
Functions (3)
Components (3)
Processes (7)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Protein-Protein Interactions (43)
1 – 10 of 43
PITPNA
Novelty: 0.01901136
Score: 0.804
Data Source: STRINGDB
ZNF444
Family: TF
Novelty: 0.21564163
Score: 0.804
Data Source: STRINGDB
MYO1C
Novelty: 0.00967011
Score: 0.774
Data Source: STRINGDB
MYO1E
Novelty: 0.01506519
Score: 0.749
Data Source: STRINGDB
YWHAE
Novelty: 0.00431876
Score: 0.748
Data Source: STRINGDB
CRK
Novelty: 0.00238512
Score: 0.741
Data Source: STRINGDB
PAFAH1B1
Family: Enzyme
Novelty: 0.00256206
Score: 0.71
Data Source: STRINGDB
STAB1
Novelty: 0.01303265
Score: 0.705
Data Source: STRINGDB
OLR1
Novelty: 0.00123609
Score: 0.7
Data Source: STRINGDB
AVIL
Novelty: 0.0175973
Score: 0.673
Data Source: STRINGDB
Publication Statistics
PubMed Score 107.19
PubMed score by year
PubTator Score 28.2
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword