Tbio SCARF1 Scavenger receptor class F member 1

Protein Summary

Description

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Uniprot Accession IDs

• Q14162
• A8MQ05
• O43701
• Q8NHD2
• Q8NHD3
• Q8NHD4
• Q8NHD5

Gene Name

• SCARF1

Ensembl ID

• ENST00000263071
• ENSP00000263071
• ENSG00000074660
• ENST00000434376
• ENSP00000411167
• ENST00000571272
• ENSP00000458174
• ENST00000621348
• ENSP00000481595
• ENSG00000276336
• ENST00000631462
• ENSP00000487665
• ENST00000632317
• ENSP00000488776

Symbol

• KIAA0149
• SREC
• SREC
• SREC1
• SREC-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.77
cell type or tissue	0.73
tissue sample	0.71
biological process	0.65
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Receptor / Scavenger Receptor Class F Member 1

Protein / Cell Adhesion Molecule / Scavenger Receptor Class F Member 1

DTO Classes

Protein / Receptor / Scavenger Receptor Class F Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.4   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.4   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0