Tbio SCARF1 Scavenger receptor class F member 1

Protein Summary

Description

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Uniprot Accession IDs

• Q14162
• A8MQ05
• O43701
• Q8NHD2
• Q8NHD3
• Q8NHD4
• Q8NHD5

Gene Name

• SCARF1

Ensembl ID

• ENST00000263071
• ENSP00000263071
• ENSG00000074660
• ENST00000434376
• ENSP00000411167
• ENST00000571272
• ENSP00000458174
• ENST00000621348
• ENSP00000481595
• ENSG00000276336
• ENST00000631462
• ENSP00000487665
• ENST00000632317
• ENSP00000488776

Symbol

• KIAA0149
• SREC
• SREC
• SREC1
• SREC-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.77
cell type or tissue	0.73
tissue sample	0.71
biological process	0.65
kinase perturbation	0.6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.14   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.14   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (43)

Explore Interacting Targets

1 – 10 of 43

• See Interactions on String-DB

PITPNA

Tbio

Novelty:  0.01901136

Score:  0.804

Data Source:  STRINGDB

ZNF444

Tdark

Family:  TF

Novelty:  0.21564163

Score:  0.804

Data Source:  STRINGDB

MYO1C

Tbio

Novelty:  0.00967011

Score:  0.774

Data Source:  STRINGDB

MYO1E

Tbio

Novelty:  0.01506519

Score:  0.749

Data Source:  STRINGDB

YWHAE

Tbio

Novelty:  0.00431876

Score:  0.748

Data Source:  STRINGDB

CRK

Tchem

Novelty:  0.00238512

Score:  0.741

Data Source:  STRINGDB

PAFAH1B1

Tbio

Family:  Enzyme

Novelty:  0.00256206

Score:  0.71

Data Source:  STRINGDB

STAB1

Tbio

Novelty:  0.01303265

Score:  0.705

Data Source:  STRINGDB

OLR1

Tbio

Novelty:  0.00123609

Score:  0.7

Data Source:  STRINGDB

AVIL

Tbio

Novelty:  0.0175973

Score:  0.673

Data Source:  STRINGDB

Pathways (3)

Reactome (3)

Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782
Reactome	Scavenging by Class F Receptors	6 targets	R-HSA-3000484
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782
Scavenging by Class F Receptors	6 targets	R-HSA-3000484
Vesicle-mediated transport	725 targets	R-HSA-5653656

Gene Ontology Terms (13)

Functions (3)

Components (3)

Processes (7)

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1 – 3 of 3

GO Term	Evidence	Assigned by
low-density lipoprotein particle binding	Inferred from Direct Assay (IDA)	UniProtKB
scavenger receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
transmembrane signaling receptor activity	Traceable Author Statement (TAS)	UniProtKB

GWAS Traits (34)

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5

1 – 5 of 34

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum albumin measurement	EFO_0004535	ENSG00000074660	3	5	6		96.9
serum albumin measurement	EFO_0004535	ENSG00000276336	3	5	6		96.9
sex hormone-binding globulin measurement	EFO_0004696	ENSG00000074660	6	3	8		96.6
sex hormone-binding globulin measurement	EFO_0004696	ENSG00000276336	6	3	8		96.6
alkaline phosphatase measurement	EFO_0004533	ENSG00000074660	2	2	2	12	92.3

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1 – 5 of 34

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum albumin measurement	EFO_0004535	6		96.9
serum albumin measurement	EFO_0004535	6		96.9
sex hormone-binding globulin measurement	EFO_0004696	8		96.6
sex hormone-binding globulin measurement	EFO_0004696	8		96.6
alkaline phosphatase measurement	EFO_0004533	2	12	92.3

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
apolipoprotein B measurement
blood protein measurement
BMI-adjusted waist circumference
brain aneurysm
C-reactive protein measurement
calcium measurement
low density lipoprotein cholesterol measurement
mean platelet volume
platelet crit

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
renal/urinary system phenotype

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	scavenger receptor class F member 1	VGNC:51731	747264
Macaque	scavenger receptor class F member 1		721235
Mouse	scavenger receptor class F, member 1	MGI:2449455	380713
Cow	scavenger receptor class F member 1	VGNC:34326	616566
Pig	scavenger receptor class F member 1		100623100

Species	Name	OMA	EggNOG	Inparanoid
Chimp	scavenger receptor class F member 1
Macaque	scavenger receptor class F member 1
Mouse	scavenger receptor class F, member 1
Cow	scavenger receptor class F member 1
Pig	scavenger receptor class F member 1

Publication Statistics

PubMed Score 107.14

PubMed score by year

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PubTator Score 28.20

PubTator score by year

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