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Tbio
GIT2
ARF GTPase-activating protein GIT2

Protein Summary
Description
GTPase-activating protein for the ADP ribosylation factor family. This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-couple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355312
  • ENSP00000347464
  • ENSG00000139436
  • ENST00000361006
  • ENSP00000354282
  • ENST00000457474
  • ENSP00000391813
  • ENST00000547815
  • ENSP00000450348
  • ENST00000553118
  • ENSP00000447465

Symbol
  • KIAA0148
  • PKL
  • CAT2
  • CAT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.94
disease perturbation
0.87
transcription factor binding site profile
0.78
small molecule perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.8   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.8   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
ARHGEF6
Tbio
Novelty:  0.02162737
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
ARHGEF7
Tbio
Novelty:  0.00919946
p_int:  0.999999935
p_ni:  6.4e-8
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999999723
p_ni:  2.77e-7
Score:  0.612
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999998918
p_ni:  0.000001082
Score:  0.952
Data Source:  BioPlex,STRINGDB
NCKIPSD
Tbio
Novelty:  0.07453111
p_int:  0.999979184
p_ni:  0.000020816
Score:  0.785
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999972985
p_ni:  0.000027015
Score:  0.941
Data Source:  BioPlex,STRINGDB
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.999927816
p_ni:  0.000072184
Score:  0.535
Data Source:  BioPlex,STRINGDB
TMEM154
Tdark
Novelty:  0.08935925
p_int:  0.999913781
p_ni:  0.000086218
p_wrong:  2e-9
Data Source:  BioPlex
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.999870579
p_ni:  0.000123481
p_wrong:  0.00000594
Data Source:  BioPlex
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999724043
p_ni:  0.000275957
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
38.2
hemoglobin measurement
1
1
1
36.9
platelet count
1
1
1
35
intelligence
1
1
1
24.5
cognitive function measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
38.2
hemoglobin measurement
1
36.9
platelet count
1
35
intelligence
1
24.5
cognitive function measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GIT ArfGAP 2
VGNC:8597
452227
Macaque
GIT ArfGAP 2
708092
Mouse
MGI:1347053
26431
Rat
RGD:1359708
304546
Dog
GIT ArfGAP 2
VGNC:41230
477520
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GIT ArfGAP 2
Macaque
GIT ArfGAP 2
Mouse
Rat
Dog
GIT ArfGAP 2
Publication Statistics
PubMed Score 73.80
PubMed score by year
PubTator Score 34.85
PubTator score by year
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Related Publications
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PMID
Year
Title