Tbio SCRIB Protein scribble homolog

Protein Summary

Description

Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q14160
• Q6P496
• Q7Z5D1
• Q8WWV8
• Q96C69
• Q96GG1
• Scribble

Gene Name

• SCRIB

Ensembl ID

• ENST00000320476
• ENSP00000322938
• ENSG00000180900
• ENST00000356994
• ENSP00000349486
• ENST00000377533
• ENSP00000366756

Symbol

• CRIB1
• KIAA0147
• LAP4
• SCRB1
• VARTUL
• CRIB1
• SCRB1
• SCRIB1
• Vartul

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
transcription factor binding site profile	0.84
ligand (protein) perturbation	0.83
disease perturbation	0.79
histone modification site profile	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.28   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.28   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (122)

Explore Interacting Targets

1 – 10 of 122

• See Interactions on String-DB

PPP1CC

Tchem

Family:  Enzyme

Novelty:  0.00465946

p_int:  0.999992253

p_ni:  0.000007747

Score:  0.472

Data Source:  BioPlex,STRINGDB

PPP1CA

Tchem

Family:  Enzyme

Novelty:  0.00354658

p_int:  0.999975454

p_ni:  0.000024546

Score:  0.345

Data Source:  BioPlex,STRINGDB

LRRC6

Tbio

Novelty:  0.10994386

p_int:  0.998670653

p_ni:  0.001329347

Score:  0.237

Data Source:  BioPlex,STRINGDB

IL1R2

Tbio

Novelty:  0.00820359

p_int:  0.995642305

p_ni:  0.004357695

Data Source:  BioPlex

ZBTB44

Tdark

Family:  TF

Novelty:  0.75195191

p_int:  0.995579501

p_ni:  0.004420499

Score:  0.178

Data Source:  BioPlex,STRINGDB

RBM23

Tbio

Novelty:  0.03769792

p_int:  0.995464025

p_ni:  0.004535975

Score:  0.178

Data Source:  BioPlex,STRINGDB

CNPY3

Tbio

Novelty:  0.11473132

p_int:  0.987620148

p_ni:  0.012379852

Score:  0.33

Data Source:  BioPlex,STRINGDB

DCUN1D2

Tchem

Novelty:  1.02957984

p_int:  0.982377621

p_ni:  0.017622379

Data Source:  BioPlex

LRRC27

Tdark

Novelty:  2.37640076

p_int:  0.980283052

p_ni:  0.019716948

Score:  0.165

Data Source:  BioPlex,STRINGDB

CLEC18A

Tbio

Novelty:  0.19310456

p_int:  0.973038275

p_ni:  0.02696172

p_wrong:  5e-9

Score:  0.219

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (621)

Reactome (5)

KEGG (4)

PathwayCommons (2)

WikiPathways (610)

Asymmetric localization of PCP proteins (R-HSA-4608870)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	PCP/CE pathway	93 targets	R-HSA-4086400
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by WNT	299 targets	R-HSA-195721

Name	Explore in Pharos	Explore in Source
Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
PCP/CE pathway	93 targets	R-HSA-4086400
Signal Transduction	2704 targets	R-HSA-162582
Signaling by WNT	299 targets	R-HSA-195721

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (46)

Functions (2)

Components (16)

Processes (28)

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1 – 2 of 2

GO Term	Evidence	Assigned by
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
ionotropic glutamate receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diastolic blood pressure	EFO_0006336	2	2	2		54.4
age at menarche	EFO_0004703	1	1	1		24.5
appendicular lean mass	EFO_0004980	1	1	1		21.5
hip circumference	EFO_0005093	1	1	1		6.3
multiple sclerosis	EFO_0003885	1	1	0	1.1	3.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diastolic blood pressure	EFO_0006336	2		54.4
age at menarche	EFO_0004703	1		24.5
appendicular lean mass	EFO_0004980	1		21.5
hip circumference	EFO_0005093	1		6.3
multiple sclerosis	EFO_0003885	0	1.1	3.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell junction
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Developmental protein
Differentiation

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
appendicular lean mass
diastolic blood pressure
hip circumference
multiple sclerosis

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
craniofacial phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
limbs/digits/tail phenotype
mortality/aging
neoplasm
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	scribbled planar cell polarity protein [Source:HGNC Symbol;Acc:HGNC:30377]
Mouse	scribbled planar cell polarity	MGI:2145950	105782
Rat	scribbled planar cell polarity protein	RGD:1565055	362938
Dog	scribbled planar cell polarity protein	VGNC:45931	100685037
Horse	scribbled planar cell polarity protein	VGNC:22750	100063454

Species	Name	OMA	EggNOG	Inparanoid
Macaque	scribbled planar cell polarity protein [Source:HGNC Symbol;Acc:HGNC:30377]
Mouse	scribbled planar cell polarity
Rat	scribbled planar cell polarity protein
Dog	scribbled planar cell polarity protein
Horse	scribbled planar cell polarity protein

Publication Statistics

PubMed Score 117.28

PubMed score by year

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PubTator Score 58.34

PubTator score by year

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Related Publications

Text Mined References (90)

GeneRif Annotations (68)

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PMID	Year	Title