Tbio SCRIB Protein scribble homolog

Protein Summary

Description

Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q14160
• Q6P496
• Q7Z5D1
• Q8WWV8
• Q96C69
• Q96GG1
• Scribble

Gene Name

• SCRIB

Ensembl ID

• ENST00000320476
• ENSP00000322938
• ENSG00000180900
• ENST00000356994
• ENSP00000349486
• ENST00000377533
• ENSP00000366756

Symbol

• CRIB1
• KIAA0147
• LAP4
• SCRB1
• VARTUL
• CRIB1
• SCRB1
• SCRIB1
• Vartul

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
transcription factor binding site profile	0.84
ligand (protein) perturbation	0.83
disease perturbation	0.79
histone modification site profile	0.79

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.95   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.95   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (10)

1 – 5 of 10

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (621)

Reactome (5)

KEGG (4)

PathwayCommons (2)

WikiPathways (610)

Asymmetric localization of PCP proteins (R-HSA-4608870)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	PCP/CE pathway	93 targets	R-HSA-4086400
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by WNT	299 targets	R-HSA-195721

Name	Explore in Pharos	Explore in Source
Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
PCP/CE pathway	93 targets	R-HSA-4086400
Signal Transduction	2704 targets	R-HSA-162582
Signaling by WNT	299 targets	R-HSA-195721

Gene Ontology Terms (46)

Functions (2)

Components (16)

Processes (28)

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1 – 2 of 2

GO Term	Evidence	Assigned by
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
ionotropic glutamate receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (122)

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1 – 10 of 122

• See Interactions on String-DB

PPP1CC

Tchem

Family: Enzyme

Novelty: 0.00465946

p_int: 0.999992253

p_ni: 0.000007747

Score: 0.472

Data Source: BioPlex,STRINGDB

PPP1CA

Tchem

Family: Enzyme

Novelty: 0.00354658

p_int: 0.999975454

p_ni: 0.000024546

Score: 0.345

Data Source: BioPlex,STRINGDB

LRRC6

Tbio

Novelty: 0.10994386

p_int: 0.998670653

p_ni: 0.001329347

Score: 0.237

Data Source: BioPlex,STRINGDB

IL1R2

Tbio

Novelty: 0.00820359

p_int: 0.995642305

p_ni: 0.004357695

Data Source: BioPlex

ZBTB44

Tdark

Family: TF

Novelty: 0.75195191

p_int: 0.995579501

p_ni: 0.004420499

Score: 0.178

Data Source: BioPlex,STRINGDB

RBM23

Tbio

Novelty: 0.03769792

p_int: 0.995464025

p_ni: 0.004535975

Score: 0.178

Data Source: BioPlex,STRINGDB

CNPY3

Tbio

Novelty: 0.11473132

p_int: 0.987620148

p_ni: 0.012379852

Score: 0.33

Data Source: BioPlex,STRINGDB

DCUN1D2

Tdark

Novelty: 1.02957984

p_int: 0.982377621

p_ni: 0.017622379

Data Source: BioPlex

LRRC27

Tdark

Novelty: 2.37640076

p_int: 0.980283052

p_ni: 0.019716948

Score: 0.165

Data Source: BioPlex,STRINGDB

CLEC18A

Tbio

Novelty: 0.19310456

p_int: 0.973038275

p_ni: 0.02696172

p_wrong: 5e-9

Score: 0.219

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  107.95

PubMed score by year

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PubTator Score  58.34

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Cell junction
Cell membrane
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Coiled coil
Complete proteome
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Developmental protein
Differentiation

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
craniofacial phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
limbs/digits/tail phenotype
mortality/aging
neoplasm
nervous system phenotype