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Tbio
SCRIB
Protein scribble homolog

Protein Summary
Description
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320476
  • ENSP00000322938
  • ENSG00000180900
  • ENST00000356994
  • ENSP00000349486
  • ENST00000377533
  • ENSP00000366756

Symbol
  • CRIB1
  • KIAA0147
  • LAP4
  • SCRB1
  • VARTUL
  • CRIB1
  • SCRB1
  • SCRIB1
  • Vartul
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83
disease perturbation
0.79
histone modification site profile
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.95   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.95   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
scribbled planar cell polarity protein [Source:HGNC Symbol;Acc:HGNC:30377]
Mouse
MGI:2145950
105782
Rat
RGD:1565055
362938
Dog
scribbled planar cell polarity protein
VGNC:45931
100685037
Horse
scribbled planar cell polarity protein
VGNC:22750
100063454
Species
Name
OMA
EggNOG
Inparanoid
Macaque
scribbled planar cell polarity protein [Source:HGNC Symbol;Acc:HGNC:30377]
Mouse
Rat
Dog
scribbled planar cell polarity protein
Horse
scribbled planar cell polarity protein
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14160-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (621)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
PCP/CE pathway
Reactome
Signal Transduction
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
PCP/CE pathway
Signal Transduction
Signaling by WNT
Gene Ontology Terms (46)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (122)
1 – 10 of 122
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999992253
p_ni: 0.000007747
Score: 0.472
Data Source: BioPlex,STRINGDB
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.999975454
p_ni: 0.000024546
Score: 0.345
Data Source: BioPlex,STRINGDB
LRRC6
Tbio
Novelty: 0.10994386
p_int: 0.998670653
p_ni: 0.001329347
Score: 0.237
Data Source: BioPlex,STRINGDB
IL1R2
Tbio
Novelty: 0.00820359
p_int: 0.995642305
p_ni: 0.004357695
Data Source: BioPlex
ZBTB44
Tdark
Family: TF
Novelty: 0.75195191
p_int: 0.995579501
p_ni: 0.004420499
Score: 0.178
Data Source: BioPlex,STRINGDB
RBM23
Tbio
Novelty: 0.03769792
p_int: 0.995464025
p_ni: 0.004535975
Score: 0.178
Data Source: BioPlex,STRINGDB
CNPY3
Tbio
Novelty: 0.11473132
p_int: 0.987620148
p_ni: 0.012379852
Score: 0.33
Data Source: BioPlex,STRINGDB
DCUN1D2
Tdark
Novelty: 1.02957984
p_int: 0.982377621
p_ni: 0.017622379
Data Source: BioPlex
LRRC27
Tdark
Novelty: 2.37640076
p_int: 0.980283052
p_ni: 0.019716948
Score: 0.165
Data Source: BioPlex,STRINGDB
CLEC18A
Tbio
Novelty: 0.19310456
p_int: 0.973038275
p_ni: 0.02696172
p_wrong: 5e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  107.95

PubMed score by year
PubTator Score  58.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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