Tbio ARHGEF7 Rho guanine nucleotide exchange factor 7

Protein Summary

Description

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q14155
• B1ALK6
• B1ALK8
• Q3LIA4
• Q5W9H0
• Q6P9G3
• Q6PII2
• Q86W63
• Q8N3M1

Gene Name

• ARHGEF7

Ensembl ID

• ENST00000317133
• ENSP00000325994
• ENSG00000102606
• ENST00000375723
• ENSP00000364875
• ENST00000375736
• ENSP00000364888
• ENST00000375739
• ENSP00000364891
• ENST00000375741
• ENSP00000364893
• ENST00000426073
• ENSP00000397068

Symbol

• COOL1
• KIAA0142
• P85SPR
• PAK3BP
• PIXB
• P50
• P85
• PAK3
• PIXB
• COOL1
• P50BP
• COOL-1
• P85SPR
• BETA-PIX
• P85COOL1
• Nbla10314

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
drug perturbation	1
kinase perturbation	0.93
protein domain	0.92
transcription factor perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.13   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 263   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.13   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0