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Tbio
ARHGEF7
Rho guanine nucleotide exchange factor 7

Protein Summary
Description
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317133
  • ENSP00000325994
  • ENSG00000102606
  • ENST00000375723
  • ENSP00000364875
  • ENST00000375736
  • ENSP00000364888
  • ENST00000375739
  • ENSP00000364891
  • ENST00000375741
  • ENSP00000364893
  • ENST00000426073
  • ENSP00000397068

Symbol
  • COOL1
  • KIAA0142
  • P85SPR
  • PAK3BP
  • PIXB
  • P50
  • P85
  • PAK3
  • PIXB
  • COOL1
  • P50BP
  • COOL-1
  • P85SPR
  • BETA-PIX
  • P85COOL1
  • Nbla10314
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
drug perturbation
1
kinase perturbation
0.93
protein domain
0.92
transcription factor perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.77   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.77   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
ARHGEF6
Tbio
Novelty:  0.02162737
p_int:  0.999999999
p_ni:  1e-9
p_wrong:  1e-9
Score:  0.986
Data Source:  BioPlex,STRINGDB
PAK3
Tchem
Family:  Kinase
Novelty:  0.02949319
p_int:  0.999999995
p_ni:  5e-9
Score:  0.973
Data Source:  BioPlex,Reactome,STRINGDB
GIT2
Tbio
Family:  Enzyme
Novelty:  0.01530665
p_int:  0.999999935
p_ni:  6.4e-8
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
PAK2
Tchem
Family:  Kinase
Novelty:  0.0149123
p_int:  0.999999862
p_ni:  1.38e-7
Score:  0.975
Data Source:  BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.999999853
p_ni:  1.48e-7
Score:  0.43
Data Source:  BioPlex,STRINGDB
GIT1
Tbio
Family:  Enzyme
Novelty:  0.01022741
p_int:  0.999999013
p_ni:  9.88e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.99999878
p_ni:  0.00000122
Score:  0.647
Data Source:  BioPlex,STRINGDB
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999998738
p_ni:  0.000001262
Score:  0.653
Data Source:  BioPlex,STRINGDB
PAK1
Tchem
Family:  Kinase
Novelty:  0.00411227
p_int:  0.999998355
p_ni:  0.000001646
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999993729
p_ni:  0.000006271
Score:  0.955
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
1 – 5 of 6
CHRM3
Tclin
Family:  GPCR
KEGG Distance:  3
Common Pathways:  1
CHRM5
Tclin
Family:  GPCR
KEGG Distance:  3
Common Pathways:  1
BDKRB2
Tclin
Family:  GPCR
KEGG Distance:  3
Common Pathways:  1
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  3
Common Pathways:  1
CHRM4
Tclin
Family:  GPCR
KEGG Distance:  3
Common Pathways:  1
Pathways (36)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAC1 downstream of NMDARs
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Activation of RAC1 downstream of NMDARs
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
49.5
body mass index
1
1
1
45.7
visceral adipose tissue measurement
1
1
1
38.8
insomnia measurement
1
1
0
1
28.1
skin aging measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
49.5
body mass index
1
45.7
visceral adipose tissue measurement
1
38.8
insomnia measurement
0
1
28.1
skin aging measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 7
VGNC:13067
452673
Macaque
Rho guanine nucleotide exchange factor 7
695530
Mouse
MGI:1860493
54126
Rat
RGD:620624
114559
Dog
Rho guanine nucleotide exchange factor 7
485552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 7
Macaque
Rho guanine nucleotide exchange factor 7
Mouse
Rat
Dog
Rho guanine nucleotide exchange factor 7
Publication Statistics
PubMed Score 112.77
PubMed score by year
PubTator Score 53.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title