Tbio DELE1 DAP3-binding cell death enhancer 1

Protein Summary

Description

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Uniprot Accession IDs

• Q14154
• Q969R4
• Q96EU9

Gene Name

• DELE1

Ensembl ID

• ENST00000194118
• ENSP00000194118
• ENSG00000081791
• ENST00000432126
• ENSP00000396225

Symbol

• DELE
• KIAA0141
• DELE
• KIAA0141

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
transcription factor perturbation	0.96
histone modification site profile	0.87
microRNA	0.73
cell type or tissue	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.04   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.04   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0