EIF3A
Eukaryotic translation initiation factor 3 subunit A
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 0.96 | ||
hub protein | 0.88 | ||
virus perturbation | 0.88 | ||
transcription factor binding site profile | 0.86 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Eukaryotic Translation Initiation | ||||
Reactome | Formation of a pool of free 40S subunits | ||||
Reactome | Formation of the ternary complex, and subsequently, the 43S complex | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||||
Cap-dependent Translation Initiation | ||||
Eukaryotic Translation Initiation | ||||
Formation of a pool of free 40S subunits | ||||
Formation of the ternary complex, and subsequently, the 43S complex | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-UniRule | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 1 | 53.3 | ||||||
neutrophil count | 1 | 1 | 1 | 50.6 | |||||
platelet crit | 1 | 1 | 1 | 45.7 | |||||
myeloid white cell count | 1 | 1 | 1 | 45.2 | |||||
BMI-adjusted waist circumference | 1 | 1 | 1 | 21.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
1 | 53.3 | ||||||
neutrophil count | 1 | 50.6 | |||||
platelet crit | 1 | 45.7 | |||||
myeloid white cell count | 1 | 45.2 | |||||
BMI-adjusted waist circumference | 1 | 21.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | eukaryotic translation initiation factor 3 subunit A | VGNC:5445 | 466216 | |||||
Mouse | MGI:95301 | 13669 | ||||||
Rat | RGD:1307269 | 292148 | ||||||
Dog | eukaryotic translation initiation factor 3 subunit A | VGNC:40268 | 486914 | |||||
Horse | eukaryotic translation initiation factor 3 subunit A | VGNC:17488 | 100066047 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | eukaryotic translation initiation factor 3 subunit A | |||||
Mouse | ||||||
Rat | ||||||
Dog | eukaryotic translation initiation factor 3 subunit A | |||||
Horse | eukaryotic translation initiation factor 3 subunit A | |||||
PMID | Year | Title |
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