Tbio EIF3A Eukaryotic translation initiation factor 3 subunit A

Protein Summary

Description

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Uniprot Accession IDs

• Q14152
• B1AMV5
• B4DYS1
• F5H335
• O00653
• Q15778
• eIF3a

Gene Name

• EIF3A

Ensembl ID

• ENST00000369144
• ENSP00000358140
• ENSG00000107581
• ENST00000541549
• ENSP00000438178

Symbol

• EIF3S10
• KIAA0139
• EIF3
• P167
• p180
• p185
• TIF32
• EIF3S10
• eIF3-p170
• eIF3-theta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	0.96
hub protein	0.88
virus perturbation	0.88
transcription factor binding site profile	0.86

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 3 Subunit A

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 3 Subunit A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.68   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 252   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.68   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (324)

Explore Interacting Targets

1 – 10 of 324

• See Interactions on String-DB

EIF3E

Tbio

Novelty:  0.02154456

p_int:  0.999995496

p_ni:  0.000004504

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3M

Tbio

Novelty:  0.0174915

p_int:  0.999991829

p_ni:  0.000008171

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3H

Tbio

Novelty:  0.02564681

p_int:  0.999990805

p_ni:  0.000009195

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3I

Tbio

Novelty:  0.04398155

p_int:  0.999989646

p_ni:  0.000010354

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3D

Tbio

Novelty:  0.0360717

p_int:  0.999974041

p_ni:  0.000025959

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3L

Tbio

Novelty:  0.11054104

p_int:  0.999973584

p_ni:  0.000026416

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3F

Tbio

Novelty:  0.0319772

p_int:  0.999936373

p_ni:  0.000063627

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF3G

Tbio

Novelty:  0.04737601

p_int:  0.999847015

p_ni:  0.000152985

Score:  0.999

Data Source:  BioPlex,STRINGDB

EIF4A1

Tchem

Novelty:  0.00269994

p_int:  0.992818894

p_ni:  0.007181106

Score:  0.988

Data Source:  BioPlex,STRINGDB

RSPH9

Tbio

Novelty:  0.08651313

p_int:  0.983007521

p_ni:  0.016992479

Score:  0.722

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (11)

KEGG (1)

PathwayCommons (1)

WikiPathways (1)

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

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5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Eukaryotic Translation Initiation	121 targets	R-HSA-72613
Reactome	Formation of a pool of free 40S subunits	103 targets	R-HSA-72689
Reactome	Formation of the ternary complex, and subsequently, the 43S complex	53 targets	R-HSA-72695

Name	Explore in Pharos	Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	61 targets	R-HSA-72662
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Eukaryotic Translation Initiation	121 targets	R-HSA-72613
Formation of a pool of free 40S subunits	103 targets	R-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complex	53 targets	R-HSA-72695

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (5)

Components (13)

Processes (6)

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1 – 5 of 5

GO Term	Evidence	Assigned by
RNA binding	Inferred from Direct Assay (IDA)	UniProtKB
mRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural molecule activity	Non-traceable Author Statement (NAS)	UniProtKB
receptor tyrosine kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl
translation initiation factor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Keratoconus	Orphanet_156071	1	1	1		53.3
neutrophil count	EFO_0004833	1	1	1		50.6
platelet crit	EFO_0007985	1	1	1		45.7
myeloid white cell count	EFO_0007988	1	1	1		45.2
BMI-adjusted waist circumference	EFO_0007789	1	1	1		21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Keratoconus	Orphanet_156071	1		53.3
neutrophil count	EFO_0004833	1		50.6
platelet crit	EFO_0007985	1		45.7
myeloid white cell count	EFO_0007988	1		45.2
BMI-adjusted waist circumference	EFO_0007789	1		21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Direct protein sequencing
Initiation factor
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
Keratoconus
myeloid white cell count
neutrophil count
platelet crit

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	eukaryotic translation initiation factor 3 subunit A	VGNC:5445	466216
Mouse	eukaryotic translation initiation factor 3, subunit A	MGI:95301	13669
Rat	eukaryotic translation initiation factor 3, subunit A	RGD:1307269	292148
Dog	eukaryotic translation initiation factor 3 subunit A	VGNC:40268	486914
Horse	eukaryotic translation initiation factor 3 subunit A	VGNC:17488	100066047

Species	Name	OMA	EggNOG	Inparanoid
Chimp	eukaryotic translation initiation factor 3 subunit A
Mouse	eukaryotic translation initiation factor 3, subunit A
Rat	eukaryotic translation initiation factor 3, subunit A
Dog	eukaryotic translation initiation factor 3 subunit A
Horse	eukaryotic translation initiation factor 3 subunit A

Publication Statistics

PubMed Score 199.68

PubMed score by year

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PubTator Score 329.94

PubTator score by year

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Related Publications

Text Mined References (90)

GeneRif Annotations (48)

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PMID	Year	Title