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Tbio
EIF3A
Eukaryotic translation initiation factor 3 subunit A

Protein Summary
Description
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369144
  • ENSP00000358140
  • ENSG00000107581
  • ENST00000541549
  • ENSP00000438178

Symbol
  • EIF3S10
  • KIAA0139
  • EIF3
  • P167
  • p180
  • p185
  • TIF32
  • EIF3S10
  • eIF3-p170
  • eIF3-theta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.96
hub protein
0.88
virus perturbation
0.88
transcription factor binding site profile
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.68   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.68   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Keratoconus
1
1
1
53.3
neutrophil count
1
1
1
50.6
platelet crit
1
1
1
45.7
myeloid white cell count
1
1
1
45.2
BMI-adjusted waist circumference
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Keratoconus
1
53.3
neutrophil count
1
50.6
platelet crit
1
45.7
myeloid white cell count
1
45.2
BMI-adjusted waist circumference
1
21.5
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 3 subunit A
VGNC:5445
466216
Mouse
MGI:95301
13669
Rat
RGD:1307269
292148
Dog
eukaryotic translation initiation factor 3 subunit A
VGNC:40268
486914
Horse
eukaryotic translation initiation factor 3 subunit A
VGNC:17488
100066047
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 3 subunit A
Mouse
Rat
Dog
eukaryotic translation initiation factor 3 subunit A
Horse
eukaryotic translation initiation factor 3 subunit A
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14152-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of a pool of free 40S subunits
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (324)
1 – 10 of 324
EIF3E
Tbio
Novelty:  0.02154456
p_int:  0.999995496
p_ni:  0.000004504
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3M
Tbio
Novelty:  0.0174915
p_int:  0.999991829
p_ni:  0.000008171
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3H
Tbio
Novelty:  0.02564681
p_int:  0.999990805
p_ni:  0.000009195
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3I
Tbio
Novelty:  0.04398155
p_int:  0.999989646
p_ni:  0.000010354
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3D
Tbio
Novelty:  0.0360717
p_int:  0.999974041
p_ni:  0.000025959
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3L
Tbio
Novelty:  0.11054104
p_int:  0.999973584
p_ni:  0.000026416
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3F
Tbio
Novelty:  0.0319772
p_int:  0.999936373
p_ni:  0.000063627
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF3G
Tbio
Novelty:  0.04737601
p_int:  0.999847015
p_ni:  0.000152985
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIF4A1
Tchem
Novelty:  0.00269994
p_int:  0.992818894
p_ni:  0.007181106
Score:  0.988
Data Source:  BioPlex,STRINGDB
RSPH9
Tbio
Novelty:  0.08651313
p_int:  0.983007521
p_ni:  0.016992479
Score:  0.722
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  199.68

PubMed score by year
PubTator Score  329.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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