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Tbio
MORC3
MORC family CW-type zinc finger protein 3

Protein Summary
Description
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400485
  • ENSP00000383333
  • ENSG00000159256

Symbol
  • KIAA0136
  • NXP2
  • ZCWCC3
  • NXP2
  • ZCW5
  • ZCWCC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
virus perturbation
0.92
transcription factor
0.83
cell type or tissue
0.71
cell line
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.77   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.77   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
40.5
diastolic blood pressure
1
1
1
26
body height
1
1
1
16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
40.5
diastolic blood pressure
1
26
body height
1
16
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MORC family CW-type zinc finger 3
VGNC:7548
458536
Macaque
MORC family CW-type zinc finger 3
695314
Mouse
MGI:2136841
338467
Rat
RGD:1307924
304074
Dog
MORC family CW-type zinc finger 3
VGNC:43318
610219
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MORC family CW-type zinc finger 3
Macaque
MORC family CW-type zinc finger 3
Mouse
Rat
Dog
MORC family CW-type zinc finger 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14149-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Interactome of polycomb repressive complex 2 (PRC2)
WikiPathways
Interactome of polycomb repressive complex 2 (PRC2)
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Endoderm Differentiation
Name
Explore in Pharos
Explore in Source
Interactome of polycomb repressive complex 2 (PRC2)
Interactome of polycomb repressive complex 2 (PRC2)
Mesodermal Commitment Pathway
Endoderm Differentiation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (31)
1 – 10 of 31
FAM9C
Tdark
Novelty: 0.86727989
p_int: 0.999999644
p_ni: 3.56e-7
Data Source: BioPlex
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.999999566
p_ni: 4.34e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
TRIM33
Tbio
Family: Epigenetic
Novelty: 0.00415877
Score: 0.689
Data Source: STRINGDB
TRIM24
Tchem
Family: Epigenetic
Novelty: 0.00532747
Score: 0.685
Data Source: STRINGDB
IFIH1
Tbio
Family: Enzyme
Novelty: 0.00111499
Score: 0.68
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.678
Data Source: STRINGDB
FAM98B
Tdark
Novelty: 0.47641513
Score: 0.674
Data Source: STRINGDB
SAE1
Tbio
Novelty: 0.01613881
Score: 0.607
Data Source: STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
Score: 0.558
Data Source: STRINGDB
MGA
Tbio
Family: TF
Novelty: 0.08965274
Score: 0.553
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.77

PubMed score by year
PubTator Score  47.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer