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Tbio
SEPT6
Septin-6

Protein Summary
Description
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343984
  • ENSP00000341524
  • ENSG00000125354
  • ENST00000354228
  • ENSP00000346169
  • ENST00000360156
  • ENSP00000353278
  • ENST00000394610
  • ENSP00000378108
  • ENST00000460411
  • ENSP00000435818
  • ENST00000489216
  • ENSP00000418715

Symbol
  • KIAA0128
  • SEP2
  • SEP2
  • SEPT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.95
disease perturbation
0.9
cellular component
0.86
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.97   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.97   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
10.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (61)
1 – 10 of 61
SEPT3
Tbio
Novelty: 0.008513
p_int: 1
Score: 0.892
Data Source: BioPlex,STRINGDB
SEPT2
Tbio
Novelty: 0.01047916
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SEPT7
Tbio
Novelty: 0.00554708
p_int: 0.999999999
p_ni: 1e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
SEPT10
Tbio
Novelty: 0.14834834
p_int: 0.999999971
p_ni: 2.9e-8
Score: 0.866
Data Source: BioPlex,STRINGDB
SEPT5
Tbio
Novelty: 0.01670991
p_int: 0.999999796
p_ni: 2.04e-7
Score: 0.965
Data Source: BioPlex,STRINGDB
SEPT4
Tbio
Novelty: 0.0037115
p_int: 0.999992139
p_ni: 0.000007861
Score: 0.995
Data Source: BioPlex,STRINGDB
SEPT14
Tbio
Novelty: 0.07155096
p_int: 0.999959929
p_ni: 2.41e-7
p_wrong: 0.000039829
Score: 0.858
Data Source: BioPlex,STRINGDB
SEPT9
Tbio
Novelty: 0.00407266
p_int: 0.999952978
p_ni: 0.000047022
Score: 0.962
Data Source: BioPlex,STRINGDB
SEPT8
Tbio
Novelty: 0.01431499
p_int: 0.999950078
p_ni: 0.000049922
Score: 0.866
Data Source: BioPlex,STRINGDB
TRIM32
Tbio
Family: Enzyme
Novelty: 0.00103526
p_int: 0.999820973
p_ni: 0.000179027
Data Source: BioPlex
Publication Statistics
PubMed Score  120.97

PubMed score by year
PubTator Score  80.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer