Tbio UBE4A Ubiquitin conjugation factor E4 A

Protein Summary

Description

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q14139
• B0YJB6
• Q2M1H0
• Q6P5T4
• Q7Z639

Gene Name

• UBE4A

Ensembl ID

• ENST00000252108
• ENSP00000252108
• ENSG00000110344
• ENST00000431736
• ENSP00000387362

Symbol

• KIAA0126
• E4
• UFD2
• UBOX2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
histone modification site profile	0.81
transcription factor binding site profile	0.8
cell type or tissue	0.68
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Ubiquitin Conjugation Factor E4 A

DTO Classes

Protein / Enzyme Modulator / Ubiquitin Conjugation Factor E4 A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.88   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 223   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.88   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0