Tbio BOP1 Ribosome biogenesis protein BOP1

Protein Summary

Description

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Uniprot Accession IDs

• Q14137
• Q969Z6
• Q96IS8
• Q96Q25
• Q9BSA7
• Q9BVM0

Gene Name

• BOP1

Ensembl ID

• ENST00000569669
• ENSP00000455106
• ENSG00000261236
• ENST00000642409
• ENSP00000495401
• ENSG00000285301

Symbol

• KIAA0124

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
kinase perturbation	0.84
histone modification site profile	0.75
small molecule perturbation	0.69
tissue	0.67

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Ribosome Biogenesis Protein Bop1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Ribosome Biogenesis Protein Bop1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.05   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.05   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0