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Tclin
PDE1C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Protein Summary
Description
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321453
  • ENSP00000318105
  • ENSG00000154678
  • ENST00000396182
  • ENSP00000379485
  • ENST00000396184
  • ENSP00000379487
  • ENST00000396191
  • ENSP00000379494

Symbol
  • Hcam3
  • DFNA74
  • hCam-3
  • cam-PDE 1C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
trait
0.86
virus perturbation
0.85
gene perturbation
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.11   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.11   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dipyridamole
Rendered image for dipyridamole
Active Ligands (46)
1 – 10 of 46
CHEMBL4128481
Rendered image for CHEMBL4128481
SCH51866
Rendered image for SCH51866
CHEMBL2431822
Rendered image for CHEMBL2431822
CHEMBL3601563
Rendered image for CHEMBL3601563
CHEMBL4644729
Rendered image for CHEMBL4644729
vinpocetine
Rendered image for vinpocetine
CHEMBL583914
Rendered image for CHEMBL583914
CHEMBL4127641
Rendered image for CHEMBL4127641
CHEMBL4129844
Rendered image for CHEMBL4129844
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
1
1
87.8
body mass index
5
4
5
84.3
cigarettes per day measurement
2
1
2
78
self reported educational attainment
4
6
5
7
75.1
intelligence
7
7
3
6
73.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
87.8
body mass index
5
84.3
cigarettes per day measurement
2
78
self reported educational attainment
5
7
75.1
intelligence
3
6
73.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 1C
VGNC:4461
463334
Macaque
phosphodiesterase 1C
693937
Mouse
MGI:108413
18575
Rat
RGD:68332
81742
Dog
phosphodiesterase 1C
VGNC:44350
475272
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 1C
Macaque
phosphodiesterase 1C
Mouse
Rat
Dog
phosphodiesterase 1C
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14123-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Ca-dependent events (R-HSA-111996)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca-dependent events
Reactome
CaM pathway
Reactome
Calmodulin induced events
Reactome
Cam-PDE 1 activation
Reactome
DAG and IP3 signaling
Name
Explore in Pharos
Explore in Source
Ca-dependent events
CaM pathway
Calmodulin induced events
Cam-PDE 1 activation
DAG and IP3 signaling
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (94)
1 – 10 of 94
PDE1A
Tclin
Family:  Enzyme
Novelty:  0.02694265
p_int:  1
Score:  0.97
Data Source:  BioPlex,STRINGDB
PDE1B
Tclin
Family:  Enzyme
Novelty:  0.02444759
p_int:  1
Score:  0.968
Data Source:  BioPlex,STRINGDB
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
p_int:  0.971846967
p_ni:  0.028153033
Score:  0.189
Data Source:  BioPlex,STRINGDB
LHX6
Tbio
Family:  TF
Novelty:  0.01603143
Score:  0.906
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.903
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.902
Data Source:  STRINGDB
AK3
Tbio
Family:  Kinase
Novelty:  0.02673466
Score:  0.901
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.9
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.9
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.872
Data Source:  STRINGDB
Publication Statistics
PubMed Score  47.11

PubMed score by year
PubTator Score  25.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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