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Tbio
VEZF1
Vascular endothelial zinc finger 1

Protein Summary
Description
Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000581208
  • ENSP00000462337
  • ENSG00000136451

Symbol
  • DB1
  • ZNF161
  • DB1
  • ZNF161
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
virus perturbation
0.92
transcription factor perturbation
0.88
transcription factor binding site profile
0.78
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (30)
1 – 10 of 30
USF1
Tbio
Family: TF
Novelty: 0.00136587
Score: 0.698
Data Source: STRINGDB
CYP2C19
Tchem
Novelty: 0.000394
Score: 0.646
Data Source: STRINGDB
ARHGAP22
Tbio
Family: Enzyme
Novelty: 0.13037853
Score: 0.62
Data Source: STRINGDB
KPNB1
Tbio
Novelty: 0.01469696
Score: 0.576
Data Source: STRINGDB
SRBD1
Tbio
Novelty: 0.18931356
Score: 0.563
Data Source: STRINGDB
NAIF1
Tbio
Novelty: 0.1179429
Score: 0.547
Data Source: STRINGDB
CYP2D6
Tclin
Family: Enzyme
Novelty: 0.00021853
Score: 0.54
Data Source: STRINGDB
FSBP
Tdark
Novelty: 0.0676606
Score: 0.534
Data Source: STRINGDB
NCLN
Tbio
Novelty: 0.10851333
Score: 0.531
Data Source: STRINGDB
DCLRE1B
Tbio
Family: Enzyme
Novelty: 0.0598925
Score: 0.528
Data Source: STRINGDB
Publication Statistics
PubMed Score  328.39

PubMed score by year
PubTator Score  106.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer