Tbio DAG1 Dystroglycan

Protein Classes

PANTHER Classes

Protein / Receptor / Dystroglycan

DTO Classes

Protein / Receptor / Dystroglycan

Protein Summary

Description

The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity. (Microbial infection) Alpha-dystroglycan acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:19324387, PubMed:17360738). Alpha-dystroglycan acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q14118
• A8K6M7
• Q969J9

Gene Name

• DAG1

Ensembl ID

• ENST00000308775
• ENSP00000312435
• ENSG00000173402
• ENST00000515359
• ENSP00000440705
• ENST00000538711
• ENSP00000438421
• ENST00000539901
• ENSP00000439334
• ENST00000541308
• ENSP00000440590
• ENST00000545947
• ENSP00000442600

Symbol

• A3a
• DAG
• AGRNR
• 156DAG
• MDDGA9
• MDDGC7
• MDDGC9
• LGMDR16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	0.98
biological process	0.93
molecular function	0.9
kinase perturbation	0.88

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 493.16   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 493.16   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (27)

Reactome (16)

KEGG (5)

PathwayCommons (1)

WikiPathways (5)

Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 5 of 16

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	2 targets	R-HSA-5083628
Reactome	Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	3 targets	R-HSA-5083633
Reactome	Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	3 targets	R-HSA-5083629
Reactome	Developmental Biology	1055 targets	R-HSA-1266738

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	2 targets	R-HSA-5083628
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	3 targets	R-HSA-5083633
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	3 targets	R-HSA-5083629
Developmental Biology	1055 targets	R-HSA-1266738

Gene Ontology Terms (76)

Functions (10)

Components (31)

Processes (35)

Items per page:

10

1 – 10 of 10

GO Term	Evidence	Assigned by
actin binding	Inferred from Direct Assay (IDA)	UniProtKB
alpha-actinin binding	Inferred from Direct Assay (IDA)	UniProtKB
SH2 domain binding	Inferred from Direct Assay (IDA)	UniProtKB
tubulin binding	Inferred from Direct Assay (IDA)	UniProtKB
vinculin binding	Inferred from Physical Interaction (IPI)	UniProtKB
structural constituent of muscle	Inferred from Mutant Phenotype (IMP)	UniProtKB
laminin-1 binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro
dystroglycan binding	Inferred from Electronic Annotation (IEA)	Ensembl
virus receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (165)

Explore Interacting Targets

1 – 10 of 165

• See Interactions on String-DB

LGALS9

Tchem

Novelty: 0.00463223

p_int: 0.999999289

p_ni: 7.11e-7

Data Source: BioPlex

PCDHGA5

Tdark

p_int: 0.999756494

p_ni: 0.000243506

Data Source: BioPlex

PCDHGB4

Tdark

Novelty: 0.62001206

p_int: 0.999233509

p_ni: 0.000766491

Data Source: BioPlex

LGALS8

Tchem

Novelty: 0.00746585

p_int: 0.99909176

p_ni: 0.00090824

Data Source: BioPlex

GINM1

Tdark

p_int: 0.998779617

p_ni: 0.001220382

Data Source: BioPlex

CEACAM21

Tdark

Novelty: 0.98765432

p_int: 0.998312301

p_ni: 0.001686187

p_wrong: 0.000001512

Data Source: BioPlex

TNF

Tclin

Novelty: 0.00001974

p_int: 0.997018043

p_ni: 0.002981832

p_wrong: 1.25e-7

Score: 0.205

Data Source: BioPlex,STRINGDB

TCTN2

Tdark

Novelty: 0.19568118

p_int: 0.995277091

p_ni: 0.004716987

p_wrong: 0.000005922

Data Source: BioPlex

PCDHB11

Tdark

Novelty: 1.5

p_int: 0.990503171

p_ni: 0.009496828

Data Source: BioPlex

TMEM106A

Tdark

Novelty: 0.49469965

p_int: 0.990205169

p_ni: 0.009794792

p_wrong: 3.9e-8

Data Source: BioPlex

Publication Statistics

PubMed Score  493.16

PubMed score by year

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PubTator Score  282.15

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MRMSVGLSLLLPLSGRTFLLLLSVVMAQSHWPSEPSEAVRDWENQLEASMHSVLSDLHEAVPTVVGIPDG

1-70

TAVVGRSFRVTIPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTLEGLPLDTDKGVHYISVSATRLGA

70-140

NGSHIPQTSSVFSIEVYPEDHSELQSVRTASPDPGEVVSSACAADEPVTVLTVILDADLTKMTPKQRIDL

140-210

LHRMRSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCSLNQNSVPDIHGVEAP

210-280

AREGAMSAQLGYPVVGWHIANKKPPLPKRVRRQIHATPTPVTAIGPPTTAIQEPPSRIVPTPTSPAIAPP

280-350

TETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIQPTRVSEAGTTVPGQIRPTMTIPGYVEPTAVATPP

350-420

TTTTKKPRVSTPKPATPSTDSTTTTTRRPTKKPRTPRPVPRVTTKVSITRLETASPPTRIRTTTSGVPRG

420-490

GEPNQRPELKNHIDRVDAWVGTYFEVKIPSDTFYDHEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQL

490-560

MYGLPDSSHVGKHEYFMHATDKGGLSAVDAFEIHVHRRPQGDRAPARFKAKFVGDPALVLNDIHKKIALV

560-630

KKLAFAFGDRNCSTITLQNITRGSIVVEWTNNTLPLEPCPKEQIAGLSRRIAEDDGKPRPAFSNALEPDF

630-700

KATSITVTGSGSCRHLQFIPVVPPRRVPSEAPPTEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGII

700-770

AMICYRKKRKGKLTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETT

770-840

PLNQDTMGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP

840-895

MRMSVGLSLLLPLSGRTFLLLLSVVMAQSHWPSEPSEAVRDWENQLEASMHSVLSDLHEAVPTVVGIPDGTAVVGRSFRVTIPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTLEGLPLDTDKGVHYISVSATRLGANGSHIPQTSSVFSIEVYPEDHSELQSVRTASPDPGEVVSSACAADEPVTVLTVILDADLTKMTPKQRIDLLHRMRSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCSLNQNSVPDIHGVEAPAREGAMSAQLGYPVVGWHIANKKPPLPKRVRRQIHATPTPVTAIGPPTTAIQEPPSRIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIQPTRVSEAGTTVPGQIRPTMTIPGYVEPTAVATPPTTTTKKPRVSTPKPATPSTDSTTTTTRRPTKKPRTPRPVPRVTTKVSITRLETASPPTRIRTTTSGVPRGGEPNQRPELKNHIDRVDAWVGTYFEVKIPSDTFYDHEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGGLSAVDAFEIHVHRRPQGDRAPARFKAKFVGDPALVLNDIHKKIALVKKLAFAFGDRNCSTITLQNITRGSIVVEWTNNTLPLEPCPKEQIAGLSRRIAEDDGKPRPAFSNALEPDFKATSITVTGSGSCRHLQFIPVVPPRRVPSEAPPTEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGKLTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETTPLNQDTMGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP

Find similar targets by:

Uniprot Keyword

3D-structure
Autocatalytic cleavage
Cell junction
Cell membrane
Complete proteome
Congenital muscular dystrophy
Cytoplasm
Cytoskeleton
Disease mutation
Disulfide bond