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Tbio
DPYS
Dihydropyrimidinase

Protein Summary
Description
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351513
  • ENSP00000276651
  • ENSG00000147647

Symbol
  • DHP
  • DHPase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
gene perturbation
0.77
virus perturbation
0.72
cell line
0.68
PubMedID
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.06   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.06   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
salivary metabolite measurement
1
1
1
93.7
1
1
0
1.4
80.1
irritability measurement
1
1
0
5.5
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
salivary metabolite measurement
1
93.7
0
1.4
80.1
irritability measurement
0
5.5
0.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dihydropyrimidinase
VGNC:887
464330
Macaque
dihydropyrimidinase
695342
Mouse
MGI:1928679
64705
Rat
RGD:68376
65135
Dog
dihydropyrimidinase
VGNC:40082
100856067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dihydropyrimidinase
Macaque
dihydropyrimidinase
Mouse
Rat
Dog
dihydropyrimidinase
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Pyrimidine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Pyrimidine catabolism
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (70)
1 – 10 of 70
DPYSL3
Tbio
Family: Enzyme
Novelty: 0.01284077
p_int: 0.999998114
p_ni: 0.000001886
Score: 0.865
Data Source: BioPlex,STRINGDB
DPYSL2
Tbio
Family: Enzyme
Novelty: 0.00374969
p_int: 0.999950103
p_ni: 0.000049897
Score: 0.853
Data Source: BioPlex,STRINGDB
DPYSL5
Tbio
Family: Enzyme
Novelty: 0.0052536
p_int: 0.999602053
p_ni: 0.000397947
Score: 0.876
Data Source: BioPlex,STRINGDB
DPYSL4
Tbio
Family: Enzyme
Novelty: 0.0449179
p_int: 0.807169763
p_ni: 0.192419345
p_wrong: 0.000410892
Data Source: BioPlex
UPB1
Tbio
Family: Enzyme
Novelty: 0.01797327
Score: 0.989
Data Source: STRINGDB
DPYD
Tclin
Family: Enzyme
Novelty: 0.00207216
Score: 0.986
Data Source: STRINGDB
AGMAT
Tbio
Family: Enzyme
Novelty: 0.03970349
Score: 0.69
Data Source: STRINGDB
GART
Tclin
Novelty: 0.00524985
Score: 0.688
Data Source: STRINGDB
AGXT2
Tbio
Family: Enzyme
Novelty: 0.02018289
Score: 0.686
Data Source: STRINGDB
UPP2
Tbio
Family: Enzyme
Novelty: 0.03788751
Score: 0.68
Data Source: STRINGDB
Publication Statistics
PubMed Score  74.06

PubMed score by year
PubTator Score  202.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer