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Tbio
NID2
Nidogen-2

Protein Summary
Description
Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions. This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216286
  • ENSP00000216286
  • ENSG00000087303

Symbol
  • NID-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.97
gene perturbation
0.91
kinase perturbation
0.84
histone modification site profile
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.91   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.91   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
1
1
0
6.5
77.7
BMI-adjusted waist-hip ratio
1
1
2
72.6
body mass index
1
1
1
36.2
triglyceride measurement
2
2
2
21.4
high density lipoprotein cholesterol measurement
1
1
1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
0
6.5
77.7
BMI-adjusted waist-hip ratio
2
72.6
body mass index
1
36.2
triglyceride measurement
2
21.4
high density lipoprotein cholesterol measurement
1
0.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nidogen 2
VGNC:3376
452905
Macaque
nidogen 2
710184
Mouse
MGI:1298229
18074
Rat
RGD:1311685
302248
Cow
nidogen 2
VGNC:32074
521854
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nidogen 2
Macaque
nidogen 2
Mouse
Rat
Cow
nidogen 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14112-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Laminin interactions
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Laminin interactions
Protein-Protein Interactions (87)
1 – 10 of 87
LYG2
Tbio
Family: Enzyme
Novelty: 0.12091256
p_int: 0.999999806
p_ni: 1.94e-7
Data Source: BioPlex
PILRA
Tbio
Novelty: 0.05154386
p_int: 0.99999918
p_ni: 8.2e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.999967004
p_ni: 0.000032785
p_wrong: 2.1e-7
Data Source: BioPlex
ETV6
Tbio
Family: TF
Novelty: 0.00151718
p_int: 0.999920149
p_ni: 0.000079848
p_wrong: 4e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.99980156
p_ni: 0.000188322
p_wrong: 0.000010118
Score: 0.185
Data Source: BioPlex,STRINGDB
MATN2
Tbio
Novelty: 0.08506252
p_int: 0.99924011
p_ni: 0.000759855
p_wrong: 3.5e-8
Score: 0.234
Data Source: BioPlex,STRINGDB
TMEM25
Tdark
Novelty: 0.35505784
p_int: 0.998891939
p_ni: 0.001108018
p_wrong: 4.3e-8
Data Source: BioPlex
PITRM1
Tchem
Family: Enzyme
Novelty: 0.08067518
p_int: 0.998834776
p_ni: 0.001164957
p_wrong: 2.67e-7
Data Source: BioPlex
EPHA7
Tchem
Family: Kinase
Novelty: 0.01065563
p_int: 0.998356155
p_ni: 0.001643769
p_wrong: 7.6e-8
Score: 0.182
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.997379827
p_ni: 0.002620121
p_wrong: 5.3e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  58.91

PubMed score by year
PubTator Score  34.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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