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Tbio
SCARB2
Lysosome membrane protein 2

Protein Summary
Description
Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. (Microbial infection) Acts as a receptor for enterovirus 71. The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264896
  • ENSP00000264896
  • ENSG00000138760
  • ENST00000452464
  • ENSP00000399154

Symbol
  • CD36L2
  • LIMP2
  • LIMPII
  • AMRF
  • EPM4
  • LGP85
  • CD36L2
  • HLGP85
  • LIMP-2
  • LIMPII
  • SR-BII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
virus perturbation
1
kinase perturbation
0.99
interacting protein
0.93


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1407.61   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1407.61   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (178)
RHCG
Tbio
Novelty:  0.00506312
p_int:  0.999671113
p_ni:  0.000328886
p_wrong:  1e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.989767311
p_ni:  0.010232689
Data Source:  BioPlex
VAMP3
Tbio
Novelty:  0.00694332
p_int:  0.978991502
p_ni:  0.021007725
p_wrong:  7.73e-7
Score:  0.92
Data Source:  BioPlex,STRINGDB
CYP26B1
Tchem
Novelty:  0.00990332
p_int:  0.97151014
p_ni:  0.028489859
p_wrong:  1e-9
Data Source:  BioPlex
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
p_int:  0.953930281
p_ni:  0.046069719
Data Source:  BioPlex
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.943117255
p_ni:  0.056882743
p_wrong:  1e-9
Data Source:  BioPlex
RAB27B
Tbio
Family:  Enzyme
Novelty:  0.01530218
p_int:  0.902423096
p_ni:  0.097576109
p_wrong:  7.94e-7
Score:  0.221
Data Source:  BioPlex,STRINGDB
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.887850479
p_ni:  0.112148858
p_wrong:  6.62e-7
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.821884117
p_ni:  0.178083561
p_wrong:  0.000032322
Data Source:  BioPlex
IGF2R
Tchem
Novelty:  0.00138374
Score:  0.967
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (70)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
93
alkaline phosphatase measurement
2
2
1
7
77.1
5
2
1
1.1
74
body mass index
3
2
4
64.8
creatinine measurement
1
2
2
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
93
alkaline phosphatase measurement
1
7
77.1
1
1.1
74
body mass index
4
64.8
creatinine measurement
2
55.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor class B member 2
VGNC:6425
461239
Macaque
scavenger receptor class B member 2
699990
Mouse
MGI:1196458
12492
Rat
RGD:621882
117106
Dog
scavenger receptor class B member 2
VGNC:45899
478435
Species
Name
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor class B member 2
Macaque
scavenger receptor class B member 2
Mouse
Rat
Dog
scavenger receptor class B member 2
Publication Statistics
PubMed Score 1407.61
PubMed score by year
PubTator Score 120.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title