Protein Summary
Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases. TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]
- ENST00000327492
- ENSP00000331305
- ENSG00000183864
- KIAA1663
- TOB4
- TROB2
- TOB4
- TOBL
- APRO5
- TROB2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.97 | ||
virus perturbation | 0.95 | ||
kinase perturbation | 0.93 | ||
transcription factor perturbation | 0.88 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.95 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 147 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.95 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 147 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0