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Tbio
COX17
Cytochrome c oxidase copper chaperone

Protein Classes
Protein Summary
Description
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein share ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261070
  • ENSP00000261070
  • ENSG00000138495
  • ENST00000468918
  • ENSP00000417805
  • ENST00000497116
  • ENSP00000417923
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.91
histone modification site profile
0.75
tissue sample
0.7
transcription factor perturbation
0.68


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.11   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.11   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
COX17, cytochrome c oxidase copper chaperone [Source:HGNC Symbol;Acc:HGNC:2264]
Mouse
MGI:1333806
12856
Rat
RGD:620548
89786
Dog
COX17, cytochrome c oxidase copper chaperone
VGNC:39536
503668
Cow
COX17, cytochrome c oxidase copper chaperone
VGNC:27631
100295800
Species
Name
OMA
EggNOG
Inparanoid
Macaque
COX17, cytochrome c oxidase copper chaperone [Source:HGNC Symbol;Acc:HGNC:2264]
Mouse
Rat
Dog
COX17, cytochrome c oxidase copper chaperone
Cow
COX17, cytochrome c oxidase copper chaperone
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (156)
1 – 10 of 156
CHCHD4
Tbio
Novelty: 0.01204944
Score: 0.995
Data Source: STRINGDB
GFER
Tchem
Family: Enzyme
Novelty: 0.00338563
Score: 0.984
Data Source: STRINGDB
COX19
Tbio
Family: Enzyme
Novelty: 0.06540633
Score: 0.967
Data Source: STRINGDB
SCO1
Tbio
Novelty: 0.01012315
Score: 0.959
Data Source: STRINGDB
CYC1
Tbio
Novelty: 0.01369865
Score: 0.947
Data Source: STRINGDB
TOMM40
Tbio
Novelty: 0.0041507
Score: 0.943
Data Source: STRINGDB
ATP5F1A
Tbio
Family: Enzyme
Novelty: 0.01052213
Score: 0.942
Data Source: STRINGDB
COX11
Tbio
Family: Enzyme
Novelty: 0.02572582
Score: 0.94
Data Source: STRINGDB
ATOX1
Tbio
Novelty: 0.00509938
Score: 0.94
Data Source: STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.11

PubMed score by year
PubTator Score  34.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer