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Tbio
COL9A2
Collagen alpha-2(IX) chain

Protein Summary
Description
Structural component of hyaline cartilage and vitreous of the eye. This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. This chain is unusual in that, unlike the other two type IX alpha chains, it contains a covalently attached glycosaminoglycan side chain. Mutations in this gene are associated with multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372748
  • ENSP00000361834
  • ENSG00000049089

Symbol
  • MED
  • EDM2
  • STL5
  • DJ39G22.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
PubMedID
0.74
tissue sample
0.67
cell line
0.65
disease
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.47   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.47   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
collagen type IX alpha 2 chain
694248
Mouse
MGI:88466
12840
Rat
RGD:1307029
362584
Dog
collagen type IX alpha 2 chain
VGNC:39486
607609
Horse
collagen type IX alpha 2 chain
VGNC:16752
100009713
Species
Name
OMA
EggNOG
Inparanoid
Macaque
collagen type IX alpha 2 chain
Mouse
Rat
Dog
collagen type IX alpha 2 chain
Horse
collagen type IX alpha 2 chain
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (41)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Axon guidance
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Axon guidance
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Protein-Protein Interactions (132)
1 – 10 of 132
COL9A1
Tbio
Novelty: 0.0160066
Score: 0.999
Data Source: Reactome,STRINGDB
COL9A3
Tbio
Novelty: 0.02556037
Score: 0.997
Data Source: Reactome,STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
Score: 0.966
Data Source: STRINGDB
COL11A1
Tbio
Novelty: 0.00594683
Score: 0.936
Data Source: STRINGDB
COL11A2
Tbio
Novelty: 0.00923441
Score: 0.935
Data Source: STRINGDB
P3H1
Tbio
Family: Enzyme
Novelty: 0.02067711
Score: 0.928
Data Source: STRINGDB
MMP3
Tchem
Novelty: 0.00041675
Score: 0.928
Data Source: STRINGDB
MMP13
Tchem
Family: Enzyme
Novelty: 0.00057893
Score: 0.928
Data Source: STRINGDB
BGN
Tbio
Novelty: 0.00139486
Score: 0.925
Data Source: STRINGDB
COL10A1
Tbio
Novelty: 0.00521991
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.47

PubMed score by year
PubTator Score  49.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer