COL9A3
Collagen alpha-3(IX) chain
Protein Summary
Structural component of hyaline cartilage and vitreous of the eye. This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in this gene are associated with multiple epiphyseal dysplasia type 3. [provided by RefSeq, Jan 2010]
- ENST00000343916
- ENSP00000341640
- ENSG00000092758
- ENST00000649368
- ENSP00000496793
- IDD
- MED
- EDM3
- DJ885L7.4.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.87 | ||
PubMedID | 0.73 | ||
cell type or tissue | 0.65 | ||
tissue sample | 0.61 | ||
small molecule perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.03 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 164 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.03 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 164 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (112)
Nearest Tclin Targets
Pathways (25)
Reactome (16)
KEGG (5)
PathwayCommons (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Axon guidance | ||||
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen chain trimerization | ||||
Reactome | Collagen degradation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Axon guidance | ||||
Collagen biosynthesis and modifying enzymes | ||||
Collagen chain trimerization | ||||
Collagen degradation | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred by Curator (IC) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 1 | 1 | 1 | 59.8 | |||||
monocyte count | 1 | 1 | 1 | 48.5 | |||||
age at menopause | 1 | 1 | 1 | 42.3 | |||||
diastolic blood pressure | 1 | 1 | 1 | 24.5 | |||||
waist circumference | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 1 | 59.8 | |||||
monocyte count | 1 | 48.5 | |||||
age at menopause | 1 | 42.3 | |||||
diastolic blood pressure | 1 | 24.5 | |||||
waist circumference | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | collagen type IX alpha 3 chain | VGNC:13837 | 745218 | |||||
Mouse | MGI:894686 | 12841 | ||||||
Rat | RGD:1310255 | 362285 | ||||||
Dog | collagen type IX alpha 3 chain | VGNC:39487 | 612430 | |||||
Horse | collagen type IX alpha 3 chain | VGNC:16753 | 100058660 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | collagen type IX alpha 3 chain | |||||
Mouse | ||||||
Rat | ||||||
Dog | collagen type IX alpha 3 chain | |||||
Horse | collagen type IX alpha 3 chain | |||||
Publication Statistics
PubMed Score 38.03
PubMed score by year
PubTator Score 45.47
PubTator score by year
Related Publications
Text Mined References (44)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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