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Tbio
COL9A3
Collagen alpha-3(IX) chain

Protein Summary
Description
Structural component of hyaline cartilage and vitreous of the eye. This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in this gene are associated with multiple epiphyseal dysplasia type 3. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343916
  • ENSP00000341640
  • ENSG00000092758
  • ENST00000649368
  • ENSP00000496793

Symbol
  • IDD
  • MED
  • EDM3
  • DJ885L7.4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.87
PubMedID
0.73
cell type or tissue
0.65
tissue sample
0.61
small molecule perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.18   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.18   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
17.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type IX alpha 3 chain
VGNC:13837
745218
Mouse
MGI:894686
12841
Rat
RGD:1310255
362285
Dog
collagen type IX alpha 3 chain
VGNC:39487
612430
Horse
collagen type IX alpha 3 chain
VGNC:16753
100058660
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type IX alpha 3 chain
Mouse
Rat
Dog
collagen type IX alpha 3 chain
Horse
collagen type IX alpha 3 chain
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14050-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Axon guidance
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Axon guidance
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Protein-Protein Interactions (112)
1 – 10 of 112
COL9A2
Tbio
Novelty: 0.01711515
Score: 0.997
Data Source: Reactome,STRINGDB
COL9A1
Tbio
Novelty: 0.0160066
Score: 0.995
Data Source: Reactome,STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
Score: 0.969
Data Source: STRINGDB
COL11A1
Tbio
Novelty: 0.00594683
Score: 0.937
Data Source: STRINGDB
COL11A2
Tbio
Novelty: 0.00923441
Score: 0.932
Data Source: STRINGDB
MMP3
Tchem
Novelty: 0.00041675
Score: 0.928
Data Source: STRINGDB
BGN
Tbio
Novelty: 0.00139486
Score: 0.925
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.925
Data Source: STRINGDB
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
Score: 0.924
Data Source: STRINGDB
COL10A1
Tbio
Novelty: 0.00521991
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.18

PubMed score by year
PubTator Score  45.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer