Tbio COL9A3 Collagen alpha-3(IX) chain

Protein Summary

Description

Structural component of hyaline cartilage and vitreous of the eye. This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in this gene are associated with multiple epiphyseal dysplasia type 3. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q14050
• Q13681
• Q9H4G9
• Q9UPE2

Gene Name

• COL9A3

Ensembl ID

• ENST00000343916
• ENSP00000341640
• ENSG00000092758
• ENST00000649368
• ENSP00000496793

Symbol

• IDD
• MED
• EDM3
• DJ885L7.4.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.87
PubMedID	0.73
cell type or tissue	0.65
tissue sample	0.61
small molecule perturbation	0.6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.66   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.66   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (25)

Reactome (16)

KEGG (5)

PathwayCommons (2)

WikiPathways (2)

Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 5 of 16

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Reactome	Collagen chain trimerization	44 targets	R-HSA-8948216
Reactome	Collagen degradation	40 targets	R-HSA-1442490

Name	Explore in Pharos	Explore in Source
Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Axon guidance	533 targets	R-HSA-422475
Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Collagen chain trimerization	44 targets	R-HSA-8948216
Collagen degradation	40 targets	R-HSA-1442490

Gene Ontology Terms (10)

Functions (2)

Components (5)

Processes (3)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
extracellular matrix structural constituent	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
extracellular matrix structural constituent conferring tensile strength	Inferred by Curator (IC)	BHF-UCL

Protein-Protein Interactions (112)

Explore Interacting Targets

1 – 10 of 112

• See Interactions on String-DB

COL9A2

Tbio

Novelty: 0.02303844

Score: 0.997

Data Source: Reactome,STRINGDB

COL9A1

Tbio

Novelty: 0.02281721

Score: 0.995

Data Source: Reactome,STRINGDB

COL2A1

Tbio

Novelty: 0.00119609

Score: 0.969

Data Source: STRINGDB

COL11A1

Tbio

Novelty: 0.00813892

Score: 0.937

Data Source: STRINGDB

COL11A2

Tbio

Novelty: 0.01141248

Score: 0.932

Data Source: STRINGDB

MMP3

Tchem

Novelty: 0.00050371

Score: 0.928

Data Source: STRINGDB

BGN

Tbio

Novelty: 0.00181025

Score: 0.925

Data Source: STRINGDB

COL5A1

Tbio

Novelty: 0.0078384

Score: 0.925

Data Source: STRINGDB

P4HA3

Tbio

Family: Enzyme

Novelty: 0.04334371

Score: 0.924

Data Source: STRINGDB

COL10A1

Tbio

Novelty: 0.00697565

Score: 0.923

Data Source: STRINGDB

Publication Statistics

PubMed Score  26.66

PubMed score by year

Reset Zoom

PubTator Score  45.47

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Sequence

MAGPRACAPLLLLLLLGELLAAAGAQRVGLPGPPGPPGPPGKPGQDGIDGEAGPPGLPGPPGPKGAPGKP

1-70

GKPGEAGLPGLPGVDGLTGRDGPPGPKGAPGERGSLGPPGPPGLGGKGLPGPPGEAGVSGPPGGIGLRGP

70-140

PGPSGLPGLPGPPGPPGPPGHPGVLPEGATDLQCPSICPPGPPGPPGMPGFKGPTGYKGEQGEVGKDGEK

140-210

GDPGPPGPAGLPGSVGLQGPRGLRGLPGPLGPPGDRGPIGFRGPPGIPGAPGKAGDRGERGPEGFRGPKG

210-280

DLGRPGPKGTPGVAGPSGEPGMPGKDGQNGVPGLDGQKGEAGRNGAPGEKGPNGLPGLPGRAGSKGEKGE

280-350

RGRAGELGEAGPSGEPGVPGDAGMPGERGEAGHRGSAGALGPQGPPGAPGVRGFQGQKGSMGDPGLPGPQ

350-420

GLRGDVGDRGPGGAAGPKGDQGIAGSDGLPGDKGELGPSGLVGPKGESGSRGELGPKGTQGPNGTSGVQG

420-490

VPGPPGPLGLQGVPGVPGITGKPGVPGKEASEQRIRELCGGMISEQIAQLAAHLRKPLAPGSIGRPGPAG

490-560

PPGPPGPPGSIGHPGARGPPGYRGPTGELGDPGPRGNQGDRGDKGAAGAGLDGPEGDQGPQGPQGVPGTS

560-630

KDGQDGAPGEPGPPGDPGLPGAIGAQGTPGICDTSACQGAVLGGVGEKSGSRSS

630-684

MAGPRACAPLLLLLLLGELLAAAGAQRVGLPGPPGPPGPPGKPGQDGIDGEAGPPGLPGPPGPKGAPGKPGKPGEAGLPGLPGVDGLTGRDGPPGPKGAPGERGSLGPPGPPGLGGKGLPGPPGEAGVSGPPGGIGLRGPPGPSGLPGLPGPPGPPGPPGHPGVLPEGATDLQCPSICPPGPPGPPGMPGFKGPTGYKGEQGEVGKDGEKGDPGPPGPAGLPGSVGLQGPRGLRGLPGPLGPPGDRGPIGFRGPPGIPGAPGKAGDRGERGPEGFRGPKGDLGRPGPKGTPGVAGPSGEPGMPGKDGQNGVPGLDGQKGEAGRNGAPGEKGPNGLPGLPGRAGSKGEKGERGRAGELGEAGPSGEPGVPGDAGMPGERGEAGHRGSAGALGPQGPPGAPGVRGFQGQKGSMGDPGLPGPQGLRGDVGDRGPGGAAGPKGDQGIAGSDGLPGDKGELGPSGLVGPKGESGSRGELGPKGTQGPNGTSGVQGVPGPPGPLGLQGVPGVPGITGKPGVPGKEASEQRIRELCGGMISEQIAQLAAHLRKPLAPGSIGRPGPAGPPGPPGPPGSIGHPGARGPPGYRGPTGELGDPGPRGNQGDRGDKGAAGAGLDGPEGDQGPQGPQGVPGTSKDGQDGAPGEPGPPGDPGLPGAIGAQGTPGICDTSACQGAVLGGVGEKSGSRSS

Find similar targets by:

Uniprot Keyword

3D-structure
Collagen
Complete proteome
Disease mutation
Dwarfism
Extracellular matrix
Glycoprotein
Hydroxylation
Polymorphism
Reference proteome