COL9A3
Collagen alpha-3(IX) chain
Protein Summary
Structural component of hyaline cartilage and vitreous of the eye. This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in this gene are associated with multiple epiphyseal dysplasia type 3. [provided by RefSeq, Jan 2010]
- ENST00000343916
- ENSP00000341640
- ENSG00000092758
- ENST00000649368
- ENSP00000496793
- IDD
- MED
- EDM3
- DJ885L7.4.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.87 | ||
PubMedID | 0.73 | ||
cell type or tissue | 0.65 | ||
tissue sample | 0.61 | ||
small molecule perturbation | 0.6 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.18 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 164 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.18 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 164 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 1 | 1 | 17.2 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
diastolic blood pressure | 1 | 17.2 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | collagen type IX alpha 3 chain | VGNC:13837 | 745218 | |||||
Mouse | MGI:894686 | 12841 | ||||||
Rat | RGD:1310255 | 362285 | ||||||
Dog | collagen type IX alpha 3 chain | VGNC:39487 | 612430 | |||||
Horse | collagen type IX alpha 3 chain | VGNC:16753 | 100058660 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | collagen type IX alpha 3 chain | |||||
Mouse | ||||||
Rat | ||||||
Dog | collagen type IX alpha 3 chain | |||||
Horse | collagen type IX alpha 3 chain | |||||
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (25)
Reactome (16)
KEGG (5)
PathwayCommons (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 16
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Axon guidance | ||||
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen chain trimerization | ||||
Reactome | Collagen degradation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Axon guidance | ||||
Collagen biosynthesis and modifying enzymes | ||||
Collagen chain trimerization | ||||
Collagen degradation | ||||
Gene Ontology Terms (10)
Functions (2)
Components (5)
Processes (3)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred by Curator (IC) | BHF-UCL | |||
Protein-Protein Interactions (112)
1 – 10 of 112
COL9A2
Novelty: 0.01711515
Score: 0.997
Data Source: Reactome,STRINGDB
COL9A1
Novelty: 0.0160066
Score: 0.995
Data Source: Reactome,STRINGDB
COL2A1
Novelty: 0.0011102
Score: 0.969
Data Source: STRINGDB
COL11A1
Novelty: 0.00594683
Score: 0.937
Data Source: STRINGDB
COL11A2
Novelty: 0.00923441
Score: 0.932
Data Source: STRINGDB
MMP3
Novelty: 0.00041675
Score: 0.928
Data Source: STRINGDB
BGN
Novelty: 0.00139486
Score: 0.925
Data Source: STRINGDB
COL5A1
Novelty: 0.00506815
Score: 0.925
Data Source: STRINGDB
P4HA3
Family: Enzyme
Novelty: 0.03832564
Score: 0.924
Data Source: STRINGDB
COL10A1
Novelty: 0.00521991
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score 37.18
PubMed score by year
PubTator Score 45.47
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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