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Tbio
BAAT
Bile acid-CoA:amino acid N-acyltransferase

Protein Summary
Description
Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very lo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259407
  • ENSP00000259407
  • ENSG00000136881
  • ENST00000395051
  • ENSP00000378491
  • ENST00000621712
  • ENSP00000484063
  • ENSG00000276559

Symbol
  • BAT
  • BACAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
molecular function
0.7
cell type or tissue
0.68
disease perturbation
0.68
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.44   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.44   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
STAU1
Tbio
Novelty:  0.00565778
p_int:  0.896207965
p_ni:  0.103792035
Score:  0.214
Data Source:  BioPlex,STRINGDB
ACOT8
Tbio
Family:  Enzyme
Novelty:  0.02218214
Score:  0.967
Data Source:  STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
Score:  0.966
Data Source:  STRINGDB
SLC27A5
Tbio
Family:  Transporter
Novelty:  0.01631425
Score:  0.965
Data Source:  STRINGDB
HAO1
Tclin
Family:  Enzyme
Novelty:  0.00054723
Score:  0.965
Data Source:  STRINGDB
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
Score:  0.963
Data Source:  STRINGDB
EHHADH
Tbio
Novelty:  0.00878193
Score:  0.961
Data Source:  STRINGDB
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
Score:  0.958
Data Source:  STRINGDB
PECR
Tbio
Family:  Enzyme
Novelty:  0.01550165
Score:  0.957
Data Source:  STRINGDB
ECH1
Tbio
Family:  Enzyme
Novelty:  0.02471875
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Peroxisomal protein import
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Peroxisomal protein import
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
3
3
9.9
95.9
C-reactive protein measurement
1
1
1
59
creatinine measurement
1
1
1
49.5
glomerular filtration rate
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
9.9
95.9
C-reactive protein measurement
1
59
creatinine measurement
1
49.5
glomerular filtration rate
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106642
12012
Rat
RGD:2190
29725
Dog
bile acid-CoA:amino acid N-acyltransferase
481635
Horse
bile acid-CoA:amino acid N-acyltransferase
100054567
Cow
acyl-coenzyme A amino acid N-acyltransferase 2
530653
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
bile acid-CoA:amino acid N-acyltransferase
Horse
bile acid-CoA:amino acid N-acyltransferase
Cow
acyl-coenzyme A amino acid N-acyltransferase 2
Publication Statistics
PubMed Score 71.44
PubMed score by year
PubTator Score 55.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title