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Tbio
COL4A6
Collagen alpha-6(IV) chain

Protein Summary
Description
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334504
  • ENSP00000334733
  • ENSG00000197565
  • ENST00000372216
  • ENSP00000361290

Symbol
  • DFNX6
  • DELXq22.3
  • CXDELq22.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.78
kinase perturbation
0.71
tissue sample
0.69
histone modification site profile
0.63
cellular component
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.03   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.03   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type IV alpha 6 chain
VGNC:10729
465804
Macaque
collagen type IV alpha 6 chain
703707
Mouse
MGI:2152695
94216
Dog
collagen type IV alpha 6 chain
VGNC:39477
403840
Horse
collagen type IV alpha 6 chain
VGNC:16743
100060112
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type IV alpha 6 chain
Macaque
collagen type IV alpha 6 chain
Mouse
Dog
collagen type IV alpha 6 chain
Horse
collagen type IV alpha 6 chain
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14031-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (32)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Collagen biosynthesis and modifying enzymes
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Collagen biosynthesis and modifying enzymes
Protein-Protein Interactions (130)
1 – 10 of 130
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
p_int: 0.999999981
p_ni: 1.6e-8
p_wrong: 4e-9
Score: 0.932
Data Source: BioPlex,STRINGDB
LAIR2
Tbio
Novelty: 0.06117644
p_int: 0.999997546
p_ni: 0.000002092
p_wrong: 3.62e-7
Data Source: BioPlex
PLOD3
Tbio
Family: Enzyme
Novelty: 0.02211629
p_int: 0.999941407
p_ni: 0.000002133
p_wrong: 0.000056459
Score: 0.92
Data Source: BioPlex,STRINGDB
FKBP9
Tbio
Family: Enzyme
Novelty: 0.16472204
p_int: 0.999581134
p_ni: 0.000415945
p_wrong: 0.000002921
Score: 0.279
Data Source: BioPlex,STRINGDB
MMP2
Tchem
Family: Enzyme
Novelty: 0.00012762
p_int: 0.891266364
p_ni: 0.00002707
p_wrong: 0.108706566
Score: 0.303
Data Source: BioPlex,STRINGDB
COL8A2
Tbio
Novelty: 0.01672103
p_int: 0.807418797
p_ni: 0.000032069
p_wrong: 0.192549135
Score: 0.931
Data Source: BioPlex,STRINGDB
COL4A5
Tbio
Novelty: 0.00283701
Score: 0.963
Data Source: Reactome,STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.932
Data Source: STRINGDB
COL5A2
Tbio
Novelty: 0.01352973
Score: 0.93
Data Source: STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.03

PubMed score by year
PubTator Score  33.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer