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Tbio
CNGB1
Cyclic nucleotide-gated cation channel beta-1

Protein Summary
Description
Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251102
  • ENSP00000251102
  • ENSG00000070729
  • ENST00000311183
  • ENSP00000311670
  • ENST00000564448
  • ENSP00000454633

Symbol
  • CNCG2
  • CNCG3L
  • CNCG4
  • RCNC2
  • CNG4
  • GAR1
  • GARP
  • RP45
  • CNCG2
  • CNCG4
  • GARP2
  • RCNC2
  • RCNCb
  • CNCG3L
  • CNGB1B
  • RCNCbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
cellular component
0.81
biological process
0.74
protein domain
0.58
microRNA
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.72   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.72   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
PDE6A
Tclin
Family:  Enzyme
Novelty:  0.02680494
Score:  0.993
Data Source:  STRINGDB
PDE6B
Tclin
Family:  Enzyme
Novelty:  0.001105
Score:  0.993
Data Source:  STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.988
Data Source:  STRINGDB
CNGA1
Tchem
Family:  IC
Novelty:  0.00848214
Score:  0.983
Data Source:  Reactome,STRINGDB
PDE6G
Tclin
Family:  Enzyme
Novelty:  0.03113994
Score:  0.963
Data Source:  STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.962
Data Source:  STRINGDB
GUCA1A
Tbio
Family:  Enzyme
Novelty:  0.01003665
Score:  0.951
Data Source:  STRINGDB
CNGA2
Tchem
Family:  IC
Novelty:  0.01050959
Score:  0.948
Data Source:  Reactome,STRINGDB
GUCA1B
Tbio
Family:  Enzyme
Novelty:  0.02031715
Score:  0.948
Data Source:  STRINGDB
GUCA1C
Tdark
Family:  Enzyme
Novelty:  0.25914047
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (33)
Activation of the phototransduction cascade (R-HSA-2485179)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
Cargo trafficking to the periciliary membrane
Cilium Assembly
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
91.9
FEV/FEC ratio
1
1
1
82.1
serum alanine aminotransferase measurement
1
1
0
6.4
44.2
1
2
0
1.1
26.6
pulmonary function measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
91.9
FEV/FEC ratio
1
82.1
serum alanine aminotransferase measurement
0
6.4
44.2
0
1.1
26.6
pulmonary function measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel beta 1
VGNC:5741
454126
Macaque
cyclic nucleotide gated channel beta 1
706073
Mouse
MGI:2664102
333329
Rat
RGD:621809
83686
Dog
cyclic nucleotide gated channel beta 1
VGNC:52122
102156683
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel beta 1
Macaque
cyclic nucleotide gated channel beta 1
Mouse
Rat
Dog
cyclic nucleotide gated channel beta 1
Publication Statistics
PubMed Score 102.72
PubMed score by year
PubTator Score 48.45
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title