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Tbio
COTL1
Coactosin-like protein

Protein Summary
Description
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262428
  • ENSP00000262428
  • ENSG00000103187

Symbol
  • CLP
  • CLP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.93
PubMedID
0.87
transcription factor binding site profile
0.81
gene perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.78   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.78   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
17
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
17
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
coactosin like F-actin binding protein 1
715376
Mouse
MGI:1919292
72042
Rat
RGD:1305498
361422
Dog
coactosin like F-actin binding protein 1
VGNC:39532
489680
Horse
coactosin like F-actin binding protein 1
VGNC:16796
100070195
Species
Name
OMA
EggNOG
Inparanoid
Macaque
coactosin like F-actin binding protein 1
Mouse
Rat
Dog
coactosin like F-actin binding protein 1
Horse
coactosin like F-actin binding protein 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14019-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (64)
1 – 10 of 64
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
Score: 0.972
Data Source: STRINGDB
FSCN1
Tbio
Novelty: 0.00221877
Score: 0.849
Data Source: STRINGDB
TIAL1
Tbio
Novelty: 0.01126806
Score: 0.822
Data Source: STRINGDB
HEBP1
Tbio
Novelty: 0.05672188
Score: 0.806
Data Source: STRINGDB
CAPG
Tbio
Novelty: 0.05173506
Score: 0.737
Data Source: STRINGDB
CAPZB
Tbio
Novelty: 0.03509224
Score: 0.725
Data Source: STRINGDB
CFL1
Tbio
Novelty: 0.00071544
Score: 0.696
Data Source: STRINGDB
JPT1
Tbio
Novelty: 0.01341629
Score: 0.677
Data Source: STRINGDB
UBE2M
Tbio
Novelty: 0.02353106
Score: 0.677
Data Source: STRINGDB
ACTR2
Tbio
Novelty: 0.00731489
Score: 0.668
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.78

PubMed score by year
PubTator Score  82.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer