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Tchem
CAMK1
Calcium/calmodulin-dependent protein kinase type 1

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'S ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256460
  • ENSP00000256460
  • ENSG00000134072

Symbol
  • CAMKI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
molecular function
0.94
protein domain
0.85
histone modification site profile
0.67
gene perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.07   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.07   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (108)
CAMK1D
Tchem
Family:  Kinase
Novelty:  0.0274233
p_int:  0.999999972
p_ni:  2.8e-8
p_wrong:  1e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
PHF19
Tbio
Family:  Epigenetic
Novelty:  0.02289037
p_int:  0.999965841
p_ni:  0.000034159
Score:  0.183
Data Source:  BioPlex,STRINGDB
CCDC106
Tdark
Novelty:  0.7081207
p_int:  0.998385169
p_ni:  0.001614831
Score:  0.258
Data Source:  BioPlex,STRINGDB
KIF20A
Tchem
Novelty:  0.01640924
p_int:  0.994623532
p_ni:  0.005376468
Score:  0.186
Data Source:  BioPlex,STRINGDB
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.992886284
p_ni:  0.007113716
Data Source:  BioPlex
ST6GALNAC3
Tbio
Family:  Enzyme
Novelty:  0.09030057
p_int:  0.991930697
p_ni:  0.008069303
Score:  0.198
Data Source:  BioPlex,STRINGDB
SRSF2
Tbio
Novelty:  0.00207072
p_int:  0.98638528
p_ni:  0.013614649
p_wrong:  7.1e-8
Data Source:  BioPlex
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.9599648
p_ni:  0.039573186
p_wrong:  0.000462014
Score:  0.703
Data Source:  BioPlex,STRINGDB
FAM153B
Tdark
Novelty:  4.34922003
p_int:  0.935116293
p_ni:  0.064883707
Score:  0.19
Data Source:  BioPlex,STRINGDB
PLA2G2D
Tchem
Family:  Enzyme
Novelty:  0.01212618
p_int:  0.933567759
p_ni:  0.066364238
p_wrong:  0.000068002
Data Source:  BioPlex
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (16)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAC1 downstream of NMDARs
Reactome
Negative regulation of NMDA receptor-mediated neuronal transmission
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Activation of RAC1 downstream of NMDARs
Negative regulation of NMDA receptor-mediated neuronal transmission
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
9.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
9.7
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase I
VGNC:10036
460153
Macaque
calcium/calmodulin dependent protein kinase I
700212
Mouse
MGI:1098535
52163
Rat
RGD:629473
171503
Dog
calcium/calmodulin dependent protein kinase I
VGNC:38677
484665
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase I
Macaque
calcium/calmodulin dependent protein kinase I
Mouse
Rat
Dog
calcium/calmodulin dependent protein kinase I
Publication Statistics
PubMed Score 78.07
PubMed score by year
PubTator Score 63.58
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title