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Tbio
CKAP5
Cytoskeleton-associated protein 5

Protein Summary
Description
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312055
  • ENSP00000310227
  • ENSG00000175216
  • ENST00000354558
  • ENSP00000346566
  • ENST00000529230
  • ENSP00000432768

Symbol
  • KIAA0097
  • TOG
  • MSPS
  • TOGp
  • CHTOG
  • ch-TOG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.98
virus perturbation
0.95
kinase perturbation
0.93
cellular component
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.36   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.36   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
7
97.6
venous thromboembolism
5
3
2
1.9
96.5
high density lipoprotein cholesterol measurement
3
3
4
92.2
bone density
3
6
6
85.3
femoral neck bone mineral density
2
2
2
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
7
97.6
venous thromboembolism
2
1.9
96.5
high density lipoprotein cholesterol measurement
4
92.2
bone density
6
85.3
femoral neck bone mineral density
2
74.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytoskeleton associated protein 5
VGNC:3151
451160
Macaque
cytoskeleton associated protein 5
714095
Mouse
MGI:1923036
75786
Rat
RGD:1563596
311191
Dog
cytoskeleton associated protein 5
VGNC:39289
475986
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytoskeleton associated protein 5
Macaque
cytoskeleton associated protein 5
Mouse
Rat
Dog
cytoskeleton associated protein 5
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14008-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Anchoring of the basal body to the plasma membrane
Cell Cycle
Gene Ontology Terms (22)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (359)
1 – 10 of 359
SLAIN2
Tbio
Novelty:  0.16273974
p_int:  0.999999781
p_ni:  2.19e-7
Score:  0.98
Data Source:  BioPlex,STRINGDB
POTEB
Tdark
Novelty:  0.48864918
p_int:  0.999988174
p_ni:  0.000011826
Data Source:  BioPlex
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.999271159
p_ni:  0.000728841
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.995880067
p_ni:  0.004119933
Score:  0.18
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.994359585
p_ni:  0.005640415
Data Source:  BioPlex
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.993871357
p_ni:  0.006128643
Data Source:  BioPlex
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.988380192
p_ni:  0.011619808
Data Source:  BioPlex
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.985512537
p_ni:  0.014487463
Data Source:  BioPlex
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.964098275
p_ni:  0.035901725
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.95715338
p_ni:  0.04284662
Data Source:  BioPlex
Publication Statistics
PubMed Score  171.36

PubMed score by year
PubTator Score  67.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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