Protein Summary
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene unde ...more
- ENST00000302987
- ENSP00000302935
- ENSG00000172349
- ENST00000394652
- ENSP00000378147
- ENST00000394660
- ENSP00000378155
- LCF
- NIL16
- PRIL16
- prIL-16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.99 | ||
hub protein | 0.71 | ||
disease | 0.7 | ||
cell line | 0.63 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 487.59 (req: < 5)
Gene RIFs: 109 (req: <= 3)
Antibodies: 697 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 487.59 (req: >= 5)
Gene RIFs: 109 (req: > 3)
Antibodies: 697 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (118)
RNF169
Family: Enzyme
Novelty: 0.28921437
p_int: 0.999882708
p_ni: 0.000113149
p_wrong: 0.000004143
Score: 0.416
Data Source: BioPlex,STRINGDB
NRBP2
Family: Kinase
Novelty: 0.28776838
p_int: 0.997773828
p_ni: 0.000181919
p_wrong: 0.002044252
Score: 0.416
Data Source: BioPlex,STRINGDB
NPB
Novelty: 0.00936692
p_int: 0.997713513
p_ni: 0.000259679
p_wrong: 0.002026808
Score: 0.161
Data Source: BioPlex,STRINGDB
ZNF148
Family: TF
Novelty: 0.01613534
p_int: 0.995038981
p_ni: 8.48e-7
p_wrong: 0.004960171
Score: 0.692
Data Source: BioPlex,STRINGDB
CAMK1
Family: Kinase
Novelty: 0.01239891
p_int: 0.908098576
p_ni: 0.091901424
Score: 0.241
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (12)
Reactome (4)
KEGG (1)
PathwayCommons (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Other interleukin signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Other interleukin signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
proâinterleukinâ16 measurement | 1 | 2 | 2 | 96.2 | |||||
hair color | 2 | 2 | 0 | 1.1 | 92.9 | ||||
blood protein measurement | 1 | 1 | 1 | 85.6 | |||||
interleukin 16 measurement | 1 | 1 | 1 | 79.9 | |||||
lymphocyte count | 2 | 1 | 2 | 72.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
proâinterleukinâ16 measurement | 2 | 96.2 | |||||
hair color | 0 | 1.1 | 92.9 | ||||
blood protein measurement | 1 | 85.6 | |||||
interleukin 16 measurement | 1 | 79.9 | |||||
lymphocyte count | 2 | 72.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | interleukin 16 | VGNC:1926 | 449644 | |||||
Macaque | interleukin 16 | 574100 | ||||||
Mouse | MGI:1270855 | 16170 | ||||||
Rat | RGD:1583872 | 116996 | ||||||
Dog | interleukin 16 | VGNC:41941 | 488762 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | interleukin 16 | |||||
Macaque | interleukin 16 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 16 | |||||
Publication Statistics
PubMed Score 487.59
PubMed score by year
PubTator Score 293.54
PubTator score by year
Related Publications
Text Mined References (146)
GeneRif Annotations (109)
Items per page:
0 of 0
PMID | Year | Title |
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