Tbio IL16 Pro-interleukin-16

Protein Summary

Description

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q14005
• A6NM20
• A8MU65
• B5TY35
• B9EGR6
• H3BVH5
• Q16435
• Q6VVE6
• Q6ZMQ7
• Q9UP18

Gene Name

• IL16

Ensembl ID

• ENST00000302987
• ENSP00000302935
• ENSG00000172349
• ENST00000394652
• ENSP00000378147
• ENST00000394660
• ENSP00000378155

Symbol

• LCF
• NIL16
• PRIL16
• prIL-16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
hub protein	0.71
disease	0.7
cell line	0.63
tissue sample	0.63

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin Superfamily / Pro-interleukin-16

DTO Classes

Protein / Signaling / Cytokine / Interleukin Superfamily / Pro-interleukin-16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 487.59   (req: < 5)

Gene RIFs: 109   (req: <= 3)

Antibodies: 697   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 487.59   (req: >= 5)

Gene RIFs: 109   (req: > 3)

Antibodies: 697   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (118)

Explore Interacting Targets

1 – 10 of 118

• See Interactions on String-DB

RNF169

Tbio

Family:  Enzyme

Novelty:  0.28921437

p_int:  0.999882708

p_ni:  0.000113149

p_wrong:  0.000004143

Score:  0.416

Data Source:  BioPlex,STRINGDB

NRBP2

Tdark

Family:  Kinase

Novelty:  0.28776838

p_int:  0.997773828

p_ni:  0.000181919

p_wrong:  0.002044252

Score:  0.416

Data Source:  BioPlex,STRINGDB

NPB

Tdark

Novelty:  0.00936692

p_int:  0.997713513

p_ni:  0.000259679

p_wrong:  0.002026808

Score:  0.161

Data Source:  BioPlex,STRINGDB

ZNF148

Tbio

Family:  TF

Novelty:  0.01613534

p_int:  0.995038981

p_ni:  8.48e-7

p_wrong:  0.004960171

Score:  0.692

Data Source:  BioPlex,STRINGDB

CAMK1

Tchem

Family:  Kinase

Novelty:  0.01239891

p_int:  0.908098576

p_ni:  0.091901424

Score:  0.241

Data Source:  BioPlex,STRINGDB

CD4

Tclin

Novelty:  0.00001217

Score:  0.969

Data Source:  Reactome,STRINGDB

CASP3

Tchem

Family:  Enzyme

Novelty:  0.00003555

Score:  0.956

Data Source:  Reactome,STRINGDB

CCL11

Tbio

Novelty:  0.00086805

Score:  0.688

Data Source:  STRINGDB

CCL5

Tchem

Novelty:  0.00032607

Score:  0.687

Data Source:  STRINGDB

IL15

Tbio

Novelty:  0.00049351

Score:  0.683

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (12)

Reactome (4)

KEGG (1)

PathwayCommons (7)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Other interleukin signaling	287 targets	R-HSA-449836
Reactome	Signaling by Interleukins	619 targets	R-HSA-449147

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Other interleukin signaling	287 targets	R-HSA-449836
Signaling by Interleukins	619 targets	R-HSA-449147

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (2)

Components (5)

Processes (6)

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GO Term	Evidence	Assigned by
CD4 receptor binding	Inferred from Physical Interaction (IPI)	CAFA
cytokine activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (9)

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1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
pro‐interleukin‐16 measurement	EFO_0010629	1	2	2		96.2
hair color	EFO_0003924	2	2	0	1.1	92.9
blood protein measurement	EFO_0007937	1	1	1		85.6
interleukin 16 measurement	EFO_0008173	1	1	1		79.9
lymphocyte count	EFO_0004587	2	1	2		72.5

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1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
pro‐interleukin‐16 measurement	EFO_0010629	2		96.2
hair color	EFO_0003924	0	1.1	92.9
blood protein measurement	EFO_0007937	1		85.6
interleukin 16 measurement	EFO_0008173	1		79.9
lymphocyte count	EFO_0004587	2		72.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative promoter usage
Alternative splicing
Chemotaxis
Complete proteome
Cytokine
Cytoplasm
Direct protein sequencing
Host-virus interaction
Nucleus

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
body height
coronary artery disease
hair color
high density lipoprotein cholesterol measurement
interleukin 16 measurement
lymphocyte count
primary biliary cirrhosis
pro‐interleukin‐16 measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	interleukin 16	VGNC:1926	449644
Macaque	interleukin 16		574100
Mouse	interleukin 16	MGI:1270855	16170
Rat	interleukin 16	RGD:1583872	116996
Dog	interleukin 16	VGNC:41941	488762

Species	Name	OMA	EggNOG	Inparanoid
Chimp	interleukin 16
Macaque	interleukin 16
Mouse	interleukin 16
Rat	interleukin 16
Dog	interleukin 16

Publication Statistics

PubMed Score 487.59

PubMed score by year

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PubTator Score 293.54

PubTator score by year

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Related Publications

Text Mined References (146)

GeneRif Annotations (109)

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PMID	Year	Title