Tbio IL16 Pro-interleukin-16

Protein Summary

Description

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q14005
• A6NM20
• A8MU65
• B5TY35
• B9EGR6
• H3BVH5
• Q16435
• Q6VVE6
• Q6ZMQ7
• Q9UP18

Gene Name

• IL16

Ensembl ID

• ENST00000302987
• ENSP00000302935
• ENSG00000172349
• ENST00000394652
• ENSP00000378147
• ENST00000394660
• ENSP00000378155

Symbol

• LCF
• NIL16
• PRIL16
• prIL-16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
hub protein	0.71
disease	0.7
cell line	0.63
tissue sample	0.63

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin Superfamily / Pro-interleukin-16

DTO Classes

Protein / Signaling / Cytokine / Interleukin Superfamily / Pro-interleukin-16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1005.97   (req: < 5)

Gene RIFs: 140   (req: <= 3)

Antibodies: 697   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1005.97   (req: >= 5)

Gene RIFs: 140   (req: > 3)

Antibodies: 697   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0