Tchem CDK13 Cyclin-dependent kinase 13

Protein Summary

Description

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• Q14004
• Q53G78
• Q6DKQ9
• Q75MH4
• Q75MH5
• Q96JN4
• Q9H4A0
• Q9H4A1
• Q9UDR4

Gene Name

• CDK13

Ensembl ID

• ENST00000181839
• ENSP00000181839
• ENSG00000065883
• ENST00000340829
• ENSP00000340557

Symbol

• CDC2L
• CDC2L5
• CHED
• KIAA1791
• CHED
• CDC2L
• CDC2L5
• hCDK13
• CHDFIDD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
molecular function	0.98
transcription factor perturbation	0.97
co-expressed gene	0.87
transcription factor binding site profile	0.85

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase 13

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase 13

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdk Family / Crk7 Subfamily / Cyclin-dependent Kinase 13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.27   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.27   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0