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Tchem
PRKG1
cGMP-dependent protein kinase 1

Protein Summary
Description
Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via sever ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373980
  • ENSP00000363092
  • ENSG00000185532
  • ENST00000373985
  • ENSP00000363097
  • ENST00000401604
  • ENSP00000384200
  • ENST00000646535
  • ENSP00000493966

Symbol
  • PRKG1B
  • PRKGR1A
  • PRKGR1B
  • PKG
  • cGK
  • AAT8
  • PKG1
  • cGK1
  • cGKI
  • cGK 1
  • PRKG1B
  • PRKGR1B
  • cGKI-BETA
  • cGKI-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
molecular function
0.99
gene perturbation
0.89
hub protein
0.82


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 601.77   (req: < 5)
Gene RIFs: 94   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 601.77   (req: >= 5)
Gene RIFs: 94   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
73.1
2
2
0
1.1
68.6
self reported educational attainment
2
2
2
67.9
mathematical ability
1
1
1
61.5
alcohol dependence measurement
1
1
0
5.6
59.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
73.1
0
1.1
68.6
self reported educational attainment
2
67.9
mathematical ability
1
61.5
alcohol dependence measurement
0
5.6
59.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase, cGMP-dependent, type I
744467
Macaque
protein kinase, cGMP-dependent, type I
703356
Mouse
MGI:108174
19091
Dog
protein kinase cGMP-dependent 1
VGNC:49948
609616
Horse
protein kinase, cGMP-dependent, type I [Source:HGNC Symbol;Acc:HGNC:9414]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase, cGMP-dependent, type I
Macaque
protein kinase, cGMP-dependent, type I
Mouse
Dog
protein kinase cGMP-dependent 1
Horse
protein kinase, cGMP-dependent, type I [Source:HGNC Symbol;Acc:HGNC:9414]
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Beta-catenin independent WNT signaling
Ca2+ pathway
Hemostasis
Immune System
Gene Ontology Terms (23)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (232)
1 – 10 of 232
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
p_int: 0.999999384
p_ni: 6.16e-7
Score: 0.461
Data Source: BioPlex,STRINGDB
ZKSCAN1
Tbio
Family: TF
Novelty: 0.08190662
p_int: 0.999998606
p_ni: 0.000001393
Score: 0.242
Data Source: BioPlex,STRINGDB
OAS2
Tbio
Family: Enzyme
Novelty: 0.01673393
p_int: 0.999950623
p_ni: 0.000049377
Score: 0.428
Data Source: BioPlex,STRINGDB
CORO2B
Tdark
Novelty: 0.30665394
p_int: 0.999485994
p_ni: 0.000514005
p_wrong: 1e-9
Score: 0.397
Data Source: BioPlex,STRINGDB
TNNT1
Tbio
Novelty: 0.00072003
p_int: 0.998406196
p_ni: 0.001593803
p_wrong: 1e-9
Score: 0.496
Data Source: BioPlex,STRINGDB
PSMC5
Tbio
Family: Enzyme
Novelty: 0.01634039
p_int: 0.837129559
p_ni: 0.16286295
p_wrong: 0.000007491
Score: 0.196
Data Source: BioPlex,STRINGDB
MRVI1
Tbio
Novelty: 0.02987514
Score: 0.994
Data Source: Reactome,STRINGDB
VASP
Tbio
Novelty: 0.00041984
Score: 0.982
Data Source: STRINGDB
GKAP1
Tdark
Family: Enzyme
Novelty: 0.35828233
Score: 0.971
Data Source: STRINGDB
RGS2
Tbio
Novelty: 0.00370571
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  601.77

PubMed score by year
PubTator Score  546.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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