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Tbio
RASGRF1
Ras-specific guanine nucleotide-releasing factor 1

Protein Summary
Description
Promotes the exchange of Ras-bound GDP by GTP. The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394745
  • ENSP00000378228
  • ENSG00000058335
  • ENST00000419573
  • ENSP00000405963
  • ENST00000558480
  • ENSP00000452781

Symbol
  • CDC25
  • GNRP
  • GRF1
  • GNRP
  • GRF1
  • CDC25
  • GRF55
  • CDC25L
  • H-GRF55
  • PP13187
  • ras-GRF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.87
trait
0.86
hub protein
0.82
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.98   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.98   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (162)
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.973
Data Source:  Reactome,STRINGDB
GRIN2B
Tclin
Family:  IC
Novelty:  0.00035058
Score:  0.971
Data Source:  Reactome,STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.957
Data Source:  Reactome,STRINGDB
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
Score:  0.955
Data Source:  STRINGDB
NTRK1
Tclin
Family:  Kinase
Novelty:  0.00033453
Score:  0.952
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.95
Data Source:  STRINGDB
GRIN1
Tclin
Family:  IC
Novelty:  0.0011807
Score:  0.948
Data Source:  Reactome,STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.948
Data Source:  STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.947
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
1 – 5 of 12
CALM3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  1
CALM2
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  1
CALM1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  1
CACNA1S
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA1B
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
Pathways (31)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
3
3
10.2
94.1
Myopia
4
4
0
1.2
91.4
age at onset
1
1
0
10.2
76.4
2
2
0
1.2
75.7
body mass index
2
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
10.2
94.1
Myopia
0
1.2
91.4
age at onset
0
10.2
76.4
0
1.2
75.7
body mass index
2
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras protein specific guanine nucleotide releasing factor 1
VGNC:6467
453575
Mouse
MGI:99694
19417
Rat
RGD:620395
192213
Dog
Ras protein specific guanine nucleotide releasing factor 1
VGNC:45370
488774
Horse
Ras protein specific guanine nucleotide releasing factor 1
VGNC:22199
100050202
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras protein specific guanine nucleotide releasing factor 1
Mouse
Rat
Dog
Ras protein specific guanine nucleotide releasing factor 1
Horse
Ras protein specific guanine nucleotide releasing factor 1
Publication Statistics
PubMed Score 118.98
PubMed score by year
PubTator Score 113.43
PubTator score by year
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Related Publications
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PMID
Year
Title