Tbio NFYC Nuclear transcription factor Y subunit gamma

Protein Summary

Description

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• Q13952
• B4DUS6
• B4DW63
• D3DPV9
• F8VWM3
• Q59GY4
• Q5T6K8
• Q5T6K9
• Q5T6L1
• Q5TZR6
• Q92869
• Q9HBX1
• Q9NXB5
• Q9UM67
• Q9UML0
• Q9UMT7

Gene Name

• NFYC

Ensembl ID

• ENST00000308733
• ENSP00000312617
• ENSG00000066136
• ENST00000372651
• ENSP00000361734
• ENST00000372652
• ENSP00000361736
• ENST00000372653
• ENSP00000361737
• ENST00000372654
• ENSP00000361738
• ENST00000425457
• ENSP00000396620
• ENST00000427410
• ENSP00000408315
• ENST00000440226
• ENSP00000414299
• ENST00000447388
• ENSP00000404427
• ENST00000456393
• ENSP00000408867

Symbol

• HSM
• CBFC
• HAP5
• CBF-C
• NF-YC
• H1TF2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
kinase perturbation	0.97
transcription factor binding site profile	0.87
transcription factor	0.82
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Transcription Factor Y Subunit Gamma

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Nuclear Transcription Factor Y Subunit Gamma

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna-directed Dna Polymerase / Nuclear Transcription Factor Y Subunit Gamma

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Dna Polymerase / Nuclear Transcription Factor Y Subunit Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.33   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 237   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.33   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0