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Tbio
NFYC
Nuclear transcription factor Y subunit gamma

Protein Summary
Description
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308733
  • ENSP00000312617
  • ENSG00000066136
  • ENST00000372651
  • ENSP00000361734
  • ENST00000372652
  • ENSP00000361736
  • ENST00000372653
  • ENSP00000361737
  • ENST00000372654
  • ENSP00000361738
  • ENST00000425457
  • ENSP00000396620
  • ENST00000427410
  • ENSP00000408315
  • ENST00000440226
  • ENSP00000414299
  • ENST00000447388
  • ENSP00000404427
  • ENST00000456393
  • ENSP00000408867

Symbol
  • HSM
  • CBFC
  • HAP5
  • CBF-C
  • NF-YC
  • H1TF2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
transcription factor binding site profile
0.87
transcription factor
0.82
transcription factor perturbation
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.33   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.33   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0