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Tchem
CBFB
Core-binding factor subunit beta

Protein Summary
Description
Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor be ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290858
  • ENSP00000290858
  • ENSG00000067955
  • ENST00000412916
  • ENSP00000415151

Symbol
  • PEBP2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.96
transcription factor perturbation
0.96
transcription factor binding site profile
0.83
microRNA
0.82


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 384   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
core-binding factor subunit beta
VGNC:13676
100612666
Mouse
MGI:99851
12400
Rat
RGD:620493
361391
Dog
core-binding factor subunit beta
VGNC:38757
479690
Horse
core-binding factor subunit beta
VGNC:51146
100065726
Species
Name
OMA
EggNOG
Inparanoid
Chimp
core-binding factor subunit beta
Mouse
Rat
Dog
core-binding factor subunit beta
Horse
core-binding factor subunit beta
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13951-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Developmental Biology
ESR-mediated signaling
Estrogen-dependent gene expression
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (233)
1 – 10 of 233
RUNX1
Tbio
Family: TF
Novelty: 0.0085181
p_int: 0.999999983
p_ni: 1.6e-8
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
RUNX2
Tbio
Family: TF
Novelty: 0.00028804
p_int: 0.99999983
p_ni: 6e-9
p_wrong: 1.64e-7
Score: 0.948
Data Source: BioPlex,Reactome,STRINGDB
RUNX3
Tbio
Family: TF
Novelty: 0.00144472
p_int: 0.999996336
p_ni: 0.000003591
p_wrong: 7.3e-8
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
GCHFR
Tbio
Family: Enzyme
Novelty: 0.04287433
p_int: 0.999718111
p_ni: 0.000277805
p_wrong: 0.000004084
Score: 0.241
Data Source: BioPlex,STRINGDB
TAS2R41
Tdark
Family: GPCR
Novelty: 0.56248837
p_int: 0.998513795
p_ni: 0.001433171
p_wrong: 0.000053035
Score: 0.209
Data Source: BioPlex,STRINGDB
ARL6IP6
Tdark
Novelty: 0.36643453
p_int: 0.911853475
p_ni: 0.015150555
p_wrong: 0.07299597
Score: 0.2
Data Source: BioPlex,STRINGDB
SERPINB5
Tbio
Novelty: 0.00192585
p_int: 0.911853475
p_ni: 0.015150555
p_wrong: 0.07299597
Score: 0.181
Data Source: BioPlex,STRINGDB
SLC25A32
Tbio
Family: Transporter
Novelty: 0.06270404
p_int: 0.871094916
p_ni: 0.018458557
p_wrong: 0.110446527
Score: 0.207
Data Source: BioPlex,STRINGDB
KMT2A
Tchem
Family: Epigenetic
Novelty: 0.00192554
Score: 0.94
Data Source: Reactome,STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.00077901
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.75

PubMed score by year
PubTator Score  256.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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