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Tclin
PDE7A
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

Protein Summary
Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379419
  • ENSP00000368730
  • ENSG00000205268
  • ENST00000396642
  • ENSP00000379881
  • ENST00000401827
  • ENSP00000385632

Symbol
  • HCP1
  • PDE7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.97
microRNA
0.93
histone modification site profile
0.75
transcription factor
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.39   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.39   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 436
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (436)
CHEMBL4877549
Rendered image for CHEMBL4877549
CHEMBL3360170
Rendered image for CHEMBL3360170
CHEMBL1915891
Rendered image for CHEMBL1915891
CHEMBL1916106
Rendered image for CHEMBL1916106
CHEMBL1915912
Rendered image for CHEMBL1915912
CHEMBL1915888
Rendered image for CHEMBL1915888
CHEMBL1915906
Rendered image for CHEMBL1915906
CHEMBL3360172
Rendered image for CHEMBL3360172
CHEMBL3360171
Rendered image for CHEMBL3360171
CHEMBL185296
Rendered image for CHEMBL185296
Protein-Protein Interactions (76)
LOX
Tchem
Family:  Enzyme
Novelty:  0.000273
p_int:  0.999985195
p_ni:  0.000014708
p_wrong:  9.7e-8
Data Source:  BioPlex
DCAF8
Tbio
Novelty:  0.12456534
p_int:  0.999807889
p_ni:  0.000188461
p_wrong:  0.00000365
Data Source:  BioPlex
THBS3
Tbio
Novelty:  0.01915634
p_int:  0.999783802
p_ni:  0.000216191
p_wrong:  7e-9
Score:  0.184
Data Source:  BioPlex,STRINGDB
UBXN11
Tbio
Novelty:  0.03165477
p_int:  0.998193013
p_ni:  0.001120701
p_wrong:  0.000686286
Score:  0.315
Data Source:  BioPlex,STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.909
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.909
Data Source:  STRINGDB
AK3
Tbio
Family:  Kinase
Novelty:  0.02673466
Score:  0.903
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.903
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.902
Data Source:  STRINGDB
ADCY10
Tchem
Family:  Enzyme
Novelty:  0.00037654
Score:  0.808
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (43)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
1
2
54
creatinine measurement
1
1
1
52.3
blood urea nitrogen measurement
1
1
1
40.1
substance abuse
1
1
1
30.2
antisocial behaviour measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
54
creatinine measurement
1
52.3
blood urea nitrogen measurement
1
40.1
substance abuse
1
30.2
antisocial behaviour measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 7A
VGNC:817
464213
Macaque
phosphodiesterase 7A
702193
Mouse
MGI:1202402
18583
Rat
RGD:68391
81744
Dog
phosphodiesterase 7A
VGNC:44363
486975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 7A
Macaque
phosphodiesterase 7A
Mouse
Rat
Dog
phosphodiesterase 7A
Publication Statistics
PubMed Score 138.39
PubMed score by year
PubTator Score 66.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title