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Tclin
PDE7A
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

Protein Summary
Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379419
  • ENSP00000368730
  • ENSG00000205268
  • ENST00000396642
  • ENSP00000379881
  • ENST00000401827
  • ENSP00000385632

Symbol
  • HCP1
  • PDE7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.97
microRNA
0.93
histone modification site profile
0.75
transcription factor
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.42   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.42   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 434
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
63.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 7A
VGNC:817
464213
Macaque
phosphodiesterase 7A
702193
Mouse
MGI:1202402
18583
Rat
RGD:68391
81744
Dog
phosphodiesterase 7A
VGNC:44363
486975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 7A
Macaque
phosphodiesterase 7A
Mouse
Rat
Dog
phosphodiesterase 7A
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13946-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (43)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (76)
1 – 10 of 76
LOX
Tbio
Family: Enzyme
Novelty: 0.000273
p_int: 0.999985195
p_ni: 0.000014708
p_wrong: 9.7e-8
Data Source: BioPlex
DCAF8
Tbio
Novelty: 0.12456534
p_int: 0.999807889
p_ni: 0.000188461
p_wrong: 0.00000365
Data Source: BioPlex
THBS3
Tbio
Novelty: 0.01915634
p_int: 0.999783802
p_ni: 0.000216191
p_wrong: 7e-9
Score: 0.184
Data Source: BioPlex,STRINGDB
UBXN11
Tbio
Novelty: 0.03165477
p_int: 0.998193013
p_ni: 0.001120701
p_wrong: 0.000686286
Score: 0.315
Data Source: BioPlex,STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.909
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.909
Data Source: STRINGDB
AK3
Tbio
Family: Kinase
Novelty: 0.02673466
Score: 0.903
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.903
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.902
Data Source: STRINGDB
ADCY10
Tchem
Family: Enzyme
Novelty: 0.00037654
Score: 0.808
Data Source: STRINGDB
Publication Statistics
PubMed Score  113.42

PubMed score by year
PubTator Score  66.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer