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Tclin
CACNA1C
Voltage-dependent L-type calcium channel subunit alpha-1C

Protein Summary
Description
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344100
  • ENSP00000341092
  • ENSG00000151067
  • ENST00000347598
  • ENSP00000266376
  • ENST00000399591
  • ENSP00000382500
  • ENST00000399595
  • ENSP00000382504
  • ENST00000399597
  • ENSP00000382506
  • ENST00000399601
  • ENSP00000382510
  • ENST00000399603
  • ENSP00000382512
  • ENST00000399606
  • ENSP00000382515
  • ENST00000399621
  • ENSP00000382530
  • ENST00000399629
  • ENSP00000382537
  • ENST00000399637
  • ENSP00000382546
  • ENST00000399638
  • ENSP00000382547
  • ENST00000399641
  • ENSP00000382549
  • ENST00000399644
  • ENSP00000382552
  • ENST00000399649
  • ENSP00000382557
  • ENST00000399655
  • ENSP00000382563
  • ENST00000402845
  • ENSP00000385724
  • ENST00000642583
  • ENSP00000494999
  • ENSG00000285479
  • ENST00000643038
  • ENSP00000494095
  • ENST00000643138
  • ENSP00000496049
  • ENST00000643701
  • ENSP00000496458
  • ENST00000643858
  • ENSP00000495576
  • ENST00000644048
  • ENSP00000494782
  • ENST00000644235
  • ENSP00000494058
  • ENST00000644369
  • ENSP00000494765
  • ENST00000644660
  • ENSP00000496749
  • ENST00000644691
  • ENSP00000494420
  • ENST00000644891
  • ENSP00000496681
  • ENST00000645584
  • ENSP00000494018
  • ENST00000645965
  • ENSP00000493890
  • ENST00000646257
  • ENSP00000493573
  • ENST00000647062
  • ENSP00000495080
  • ENST00000647327
  • ENSP00000493781
  • ENST00000647521
  • ENSP00000495678

Symbol
  • CACH2
  • CACN2
  • CACNL1A1
  • CCHL1A1
  • TS
  • LQT8
  • CACH2
  • CACN2
  • CaV1.2
  • CCHL1A1
  • CACNL1A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
molecular function
0.96
biological process
0.95
biological term
0.94
kinase
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1050.76   (req: < 5)
Gene RIFs: 230   (req: <= 3)
Antibodies: 472   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1050.76   (req: >= 5)
Gene RIFs: 230   (req: > 3)
Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 100
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 27
GWAS Traits (58)
Items per page:
1 – 5 of 58
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
7
1
1.1
98.2
11
7
1
1.1
98.2
hematocrit
4
4
4
93.7
hematocrit
4
4
4
93.7
hemoglobin measurement
3
3
3
93
Items per page:
1 – 5 of 58
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
98.2
1
1.1
98.2
hematocrit
4
93.7
hematocrit
4
93.7
hemoglobin measurement
3
93
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 C
VGNC:51248
466915
Macaque
calcium voltage-gated channel subunit alpha1 C
721721
Mouse
MGI:103013
12288
Rat
RGD:2245
24239
Dog
calcium voltage-gated channel subunit alpha1 C
VGNC:38633
403516
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 C
Macaque
calcium voltage-gated channel subunit alpha1 C
Mouse
Rat
Dog
calcium voltage-gated channel subunit alpha1 C
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13936-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (51)
Adrenaline,noradrenaline inhibits insulin secretion (R-HSA-400042)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Integration of energy metabolism
Name
Explore in Pharos
Explore in Source
Adrenaline,noradrenaline inhibits insulin secretion
Axon guidance
Cardiac conduction
Developmental Biology
Integration of energy metabolism
Gene Ontology Terms (40)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (308)
1 – 10 of 308
CALM1
Tclin
Novelty: 0.00308267
Score: 0.997
Data Source: STRINGDB
CACNB2
Tbio
Family: IC
Novelty: 0.01745218
Score: 0.997
Data Source: Reactome,STRINGDB
CACNB1
Tbio
Family: IC
Novelty: 0.06568749
Score: 0.992
Data Source: Reactome,STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.986
Data Source: STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.01744541
Score: 0.983
Data Source: Reactome,STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
Score: 0.981
Data Source: Reactome,STRINGDB
CALM2
Tclin
Novelty: 0.01876254
Score: 0.979
Data Source: STRINGDB
CACNB4
Tbio
Family: IC
Novelty: 0.01564026
Score: 0.971
Data Source: Reactome,STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.02238343
Score: 0.968
Data Source: Reactome,STRINGDB
CACNA2D2
Tclin
Family: IC
Novelty: 0.02041017
Score: 0.965
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1050.76

PubMed score by year
PubTator Score  424.34

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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