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Tclin
CACNA1C
Voltage-dependent L-type calcium channel subunit alpha-1C

Protein Summary
Description
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344100
  • ENSP00000341092
  • ENSG00000151067
  • ENST00000347598
  • ENSP00000266376
  • ENST00000399591
  • ENSP00000382500
  • ENST00000399595
  • ENSP00000382504
  • ENST00000399597
  • ENSP00000382506
  • ENST00000399601
  • ENSP00000382510
  • ENST00000399603
  • ENSP00000382512
  • ENST00000399606
  • ENSP00000382515
  • ENST00000399621
  • ENSP00000382530
  • ENST00000399629
  • ENSP00000382537
  • ENST00000399637
  • ENSP00000382546
  • ENST00000399638
  • ENSP00000382547
  • ENST00000399641
  • ENSP00000382549
  • ENST00000399644
  • ENSP00000382552
  • ENST00000399649
  • ENSP00000382557
  • ENST00000399655
  • ENSP00000382563
  • ENST00000402845
  • ENSP00000385724
  • ENST00000642583
  • ENSP00000494999
  • ENSG00000285479
  • ENST00000643038
  • ENSP00000494095
  • ENST00000643138
  • ENSP00000496049
  • ENST00000643701
  • ENSP00000496458
  • ENST00000643858
  • ENSP00000495576
  • ENST00000644048
  • ENSP00000494782
  • ENST00000644235
  • ENSP00000494058
  • ENST00000644369
  • ENSP00000494765
  • ENST00000644660
  • ENSP00000496749
  • ENST00000644691
  • ENSP00000494420
  • ENST00000644891
  • ENSP00000496681
  • ENST00000645584
  • ENSP00000494018
  • ENST00000645965
  • ENSP00000493890
  • ENST00000646257
  • ENSP00000493573
  • ENST00000647062
  • ENSP00000495080
  • ENST00000647327
  • ENSP00000493781
  • ENST00000647521
  • ENSP00000495678

Symbol
  • CACH2
  • CACN2
  • CACNL1A1
  • CCHL1A1
  • TS
  • LQT8
  • CACH2
  • CACN2
  • CaV1.2
  • CCHL1A1
  • CACNL1A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
molecular function
0.96
biological process
0.95
biological term
0.94
kinase
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1222.9   (req: < 5)
Gene RIFs: 230   (req: <= 3)
Antibodies: 472   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1222.9   (req: >= 5)
Gene RIFs: 230   (req: > 3)
Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 124
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 35